Major Histocompatibility Complex-Directed Susceptibility to Rheumatoid Arthritis
References (72)
- et al.
Natural ligand motifs of closely related HLA-DR4 molecules predict features of rheumatoid arthritis associated peptides
Biochim. Biophys. Acta
(1996) - et al.
Autoreactive T cells from a type I diabetic recognize multiple class II products
Hum. Immunol.
(1993) - et al.
Prediction of susceptibility to rheumatoid arthritis by human leukocyte antigen genotyping
- et al.
Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis
Am. J. Med
(1988) - et al.
A structural model for TCR recognition of the HLA class II shared epitope sequence implicated in susceptibility to rheumatoid arthritis
J. Autoimmun.
(1996) - et al.
Could HLA-DRB1 be the protective locus in rheumatoid arthritis?
Immunol. Today
(1995) - et al.
The susceptibility sequence to rheumatoid arthritis is a cross-reactive B cell epitope shared by the Escherichia coli heat shock protein dnaj and the histocompatibility leukocyte antigen DRB10401 molecule
J. Clin. Invest.
(1992) - et al.
HLA-DR4 and HLA-DR10 motifs that carry susceptibility to rheumatoid arthritis bind 70-kD heat shock proteins
Nat. Med.
(1996) - et al.
Serological recognition of HLA-DR allodeterminant corresponding to DNA sequence involved in gene conversion
Immunogenetics
(1988) - et al.
HLA class II sequence polymorphisms and susceptibility to rheumatoid arthritis in Greeks. The HLA-DR beta shared-epitope hypothesis accounts for the disease in only a minority of Greek patients
Arthritis Rheum.
(1992)
New perspectives on treating rheumatoid arthritis
N. Engl. J. Med.
(1995)
Destructive arthritis, rheumatoid factor, and HLA-DR4
Arthritis Rheum.
(1989)
Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles
J. Exp. Med.
(1993)
Prognostic factors in rheumatoid arthritis. Comparative study of two subsets of patients according to severity of articular damage
Br. J. Rheum.
(1995)
Naturally processed peptides from two disease-resistance-associated HLA-DR13 alleles show related sequence motifs and the effects of the dimorphism at position 86 of the HLA-DRβ chain
Proc. Natl. Acad. Sci. USA
(1995)
A distinctive peptide binding motif for HLA-DRB1°0407, an HLA-DR4 subtype not associated with rheumatoid arthritis
Immunogenetics
(1997)
The set of naturally processed peptides displayed by DR molecules is tuned by polymorphism of residue 86
Eur. J. Immunol.
(1996)
Pocket 4 of the HLA-DR(α,β1°0401) molecule is a major determinant of T cell recognition of peptide
J. Exp. Med.
(1995)
HLA-DR alleles with naturally occurring amino acid substitutions and risk for development of rheumatoid arthritis
Arthritis Rheum.
(1990)
Ancestral major histocompatibility complex DRB genes beget conserved patterns of localized polymorphisms
Proc. Natl. Acad. Sci. USA
(1996)
MHC-DRB allelic sequences incorporate distinct intragenic trans-specific segments
Tissue Antigens
(1997)
The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3
Nature
(1995)
Genetic typing of patients with inflammatory arthritis at presentation can be used to predict outcome
Arthritis Rheum.
(1994)
The shared epitope hypothesis: An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis
Arthritis Rheum.
(1987)
Allelic diversity is generated by intraexon sequence exchange at the DRB1 locus of primates
Proc. Natl. Acad. Sci. USA
(1991)
Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning
J. Exp. Med.
(1994)
Peptide binding specificity of HLA-DR4 molecules: Correlation with rheumatoid arthritis association
J. Exp. Med.
(1995)
Structural requirements for recognition of the HLA-Dw14 class II epitope: A key HLA determinant associated with rheumatoid arthritis
Proc. Natl. Acad. Sci. USA
(1990)
Novel genes in the human major histocompatibility complex class II region
Int. Arch. Allergy Immunol.
(1994)
Naturally processed peptides from rheumatoid arthritis associated and non-associated HLA-DR alleles
J. Immunol.
(1995)
MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
J. Appl. Crystallogr.
(1991)
HLA-DQB1 codon 57 is critical for peptide binding and recognition
J. Exp. Med.
(1996)
Evolution of major histocompatibility complex class II allelic diversity: Direct descent in mice and humans
Proc. Natl. Acad. Sci. USA
(1992)
Allele specificity of structural requirement for peptides bound to HLA-DRB1°0405 and -DRB1°0406 complexes: Implication for the HLA-associated susceptibility to methimazole-induced insulin autoimmune syndrome
J. Exp. Med.
(1994)
Most African-American patients with rheumatoid arthritis do not have the rheumatoid antigenic determinant (epitope)
Ann. Intern. Med.
(1995)
Structural requirements of peptide and MHC for DR(α,β1°0401)-restricted T cell antigen recognition
J. Immunol.
(1995)
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Connective Tissue Diseases
2015, Murray and Nadel's Textbook of Respiratory Medicine: Volume 1,2, Sixth EditionThe effects of RelB deficiency on lymphocyte development and function
2015, Journal of AutoimmunityCitation Excerpt :The immune and genetic aberrations in rheumatoid arthritis (RA) highlight the key role for abnormal T cell differentiation, selection and signal transduction in the pathogenesis of this disease. The strongest evidence for the role of T cells are the associations of RA (and other autoimmune disorders) with HLA-DR [43,44] and allelic variants in Lyp, CTLA4, IL2Rα and others, all directly implicated in T cell maturation and activation [45–53]. Failure to detect T cell auto reactive clones in the thymus, expansion of CD4+ cells over CD8+ cells, as well as a restrictive T cell repertoire with selective overexpansion of memory TCRVβ clones, have all been observed consistently in RA [54].
Rheumatoid arthritis
2013, Clinical Immunology: Principles and Practice: Fourth EditionGenetics of Rheumatic Diseases
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