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2018, Rheumatic Disease Clinics of North AmericaCitation Excerpt :However, tumor markers such as α-fetoprotein, prostate-specific antigen, CA-125, CA 19-9, and CA-3 have low sensitivity and specificity in screening for occult cancer in these patients. On the other hand, the presence of a monoclonal gammopathy in RA and the finding of monoclonal antibody 17-9 in Sjögren syndrome have been described as potential signs of malignant transformation.6 The association of malignancies with RA is somewhat controversial.
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