Hepatitis C virus infection and autoimmunity
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Cited by (196)
Anti-rods/rings autoantibody and IMPDH filaments: an update after fifteen years of discovery
2020, Autoimmunity ReviewsCitation Excerpt :Among cirrhosis patients, there is a 1–5% annual risk of developing hepatocellular carcinoma and a 3–6% annual risk of hepatic decompensation, which leads to death in the following year in 15–20% of cases [37]. While HCV infection itself is not an autoimmune disorder, it has been associated with a variety of serological and clinical autoimmune manifestations, including ANA, rheumatoid factor, anti-cardiolipin, anti-thyroid, anti-smooth muscle, and anti-liver/kidney/microsomal autoantibodies [38–42]. It is often not clear why autoantibodies are generated against self-antigens.
Lupus Hepatitis and Autoimmune Hepatitis (Lupoid Hepatitis)
2017, American Journal of the Medical SciencesViral Arthritis
2016, Kelley and Firestein's Textbook of Rheumatology: Volumes 1-2, Tenth EditionHepatitis C virus antibodies in high risk juvenile onset systemic lupus erythematosus
2016, Revista Brasileira de ReumatologiaCitation Excerpt :In fact, none of our 15 patients with active disease (elevated SLEDAI index) revealed a positive test for anti-HCV in spite of previous report of false positive anti-HCV serology related to lupus activity.5,11,23 Additionally, HCV has also been associated to a high variety of extra hepatic manifestations including membranoproliferative glomerulonephritis, porphyria cutanea tarda, lychen planus and thyroiditis.4–9 The notable capacity of HCV to induce autoantibodies has aroused particular interests in the possible association between SLE and HCV chronic hepatitis.6
Virus-induced preferential antibody gene-usage and its importance in humoral autoimmunity
2015, Seminars in Immunology