Progressive outer retinal necrosis in immunocompetent patients treated initially for optic neuropathy with systemic corticosteroids
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Cited by (36)
Meganuclease targeting HSV-1 protects against herpetic keratitis: Application to corneal transplants
2022, Molecular Therapy Nucleic AcidsCitation Excerpt :Because herpetic stromal keratitis is a leading cause of vision loss,12 we assessed the meganuclease’s therapeutic potential in rabbit corneal stroma. After confirming that stromal transduction followed intrastromal AAV-EGFP-vector injection and led to reporter expression (Figure 3A) and that AAV-MEGA-vector injection enabled meganuclease expression (Figure 3B), AAV-MEGA vector and rHSV-1 were injected sequentially following partial immunosuppression, known to exacerbate HSV-1 replication.13,14,15 Two weeks after stromal transfection of the AAV-CTRL vector, keratocyte infection was observed from day 1 to day 6 rHSV-1 postinoculation (Figure 3C).
Clinical and neuroradiologic characteristics in varicella zoster virus reactivation with central nervous system involvement
2022, Journal of the Neurological SciencesCitation Excerpt :The diagnosis of VZV can be challenging if a characteristic rash is absent. Supportive cerebrospinal fluid (CSF) findings may include pleocytosis, VZV RNA detection by polymerase chain reaction (PCR), [4,11,12] and CSF and serum antibody titers, [7,13–18] but sensitivity of these assays depends on the disease course [19,20]. MRI is a noninvasive diagnostic tool that can assist in delineating neurological sequelae of VZV disease, [1,21,22] yet detailed characterization of CNS VZV manifestations, especially ocular disorders, remains limited.
Optic disc edema with peripapillary serous retinal detachment as the presenting sign of necrotizing herpetic retinitis
2022, American Journal of Ophthalmology Case ReportsCitation Excerpt :Early optic disc involvement in patients with NHR is a challenging diagnosis to ascertain and can be mistaken for more common causes of optic neuropathy that are treated with systemic corticosteroids. Benz et al.13 described a woman with multiple sclerosis who developed sudden onset of decreased vision and eye pain in the setting of a relative afferent pupillary defect and was diagnosed with retrobulbar optic neuritis. Nine days following initiation of systemic corticosteroid treatment, her vision declined to count fingers and she was found to have progressive outer retinal necrosis in the affected eye.
Case series: Two cases of herpetic retinitis presenting as progressive outer retinal necrosis in immunocompetent individuals
2021, American Journal of Ophthalmology Case ReportsCitation Excerpt :Another case series in 2003 reported two patients over the age of 55 considered to be immunocompetent with findings consistent with PORN after being treated with high-dose corticosteroids for presumed optic neuropathy.6However, it is most likely that the immune status of these patients was compromised by the systemic corticosteroid treatment. In addition to high dose corticosteroids therapy, one patient was on long-term therapy for rheumatoid arthritis with anti-TNF, etanercept, while the other patient had a known diagnosis of multiple sclerosis and it was not mentioned if there was concurrent systemic treatment for this.6 Necrotizing herpetic retinitis comprises a spectrum of disease induced by latent reactivation of a herpes viruses with the resulting clinical picture depending on the host immune state.
Perioptic neuritis related with varicella-zoster virus infection preceding sixth cranial nerve palsy and progressive outer retinal necrosis in a immunocompetent patient
2017, Journal of the Neurological SciencesHerpes Simplex Virus
2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases