Clinical study
Autoimmune thyroid disease in primary Sjögren's syndrome

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      A study by Kelly et al. [7] showed a prevalence of thyroid alterations of 14% among 100 SS patients, with hypothyroidism being found in 11% and hyperthyroidism in 3%. Later on, Perez et al. [8] studied the thyroid function of 33 patients with SS and found thyroid disease and thyroid dysfunction in 45% of these patients, being autoimmune thyroiditis in 24%, hypothyroidism in 33% and hyperthyroidism in 6%. Anti-thyroperoxidase (TPO) antibodies, anti-thyroglobulin (TG) antibodies, anti-thyroxine antibodies and antitriiodiothyronine antibodies were positive in 45%, 18%, 42% and 36% of patients, respectively.

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      However, although specific to AITD, anti-thyroglobulin (TGabs) [2] and anti-thyroperoxidase (TPOabs) [2] antibodies have been reported in many patients with nonthyroidal diseases, and even in the normal population [3]. On the other hand, a high prevalence of auto antibodies directed against nonthyroid-specific antigens has been described in patients with AITD [4,5]. These observations suggest that immune reaction of patients with organ-specific autoimmune diseases may be polyclonal organ and non organ-specific auto antigens [5].

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