Clinical studyAntiphospholipid and antinuclear antibodies in patients with epilepsy or new-onset seizure disorders
Section snippets
Subjects
Blood was obtained at regularly scheduled clinical visits from 152 patients with seizure disorders after obtaining informed consent. The study was approved by the Ethics Committees of Tampere University Hospital and the University of Oulu Faculty of Medicine. Blood was processed for the collection of serum and stored in aliquots at −20°C.
Clinical records of the patients were reviewed retrospectively without knowledge of laboratory data to determine the patient’s age, use of antiepileptic drugs,
Results
The clinical characteristics of the patients are presented in Table 1. Patients with epilepsy tended to have a greater prevalence of autoantibodies (except IgM class anti-β2-glycoprotein I antibodies), which were statistically significant for IgG class anticardiolipin antibodies in newly diagnosed patients with seizure disorder, for IgM class anticardiolipin antibodies in all seizure groups, and for antinuclear antibodies in newly diagnosed patients and localization-related epilepsy Table 2,
Discussion
The major finding in our study was a stronger association between various epileptic syndromes and the prevalence of autoantibodies than between antiepileptic medications and autoantibodies. We found a substantial prevalence of anticardiolipin antibodies, anti-β2-glycoprotein I antibodies, and antinuclear antibodies among patients with newly diagnosed, untreated epileptic seizures, which strongly suggests that the occurrence of autoantibodies cannot be due to antiepileptic medications alone. In
Acknowledgements
We would like to thank T. Dyba, MSc, for performing the statistical analyses and P. Tenkilä, MA, for reviewing the manuscript for fluency in English.
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