Nuclear changes in apoptosis

doi:10.1016/0955-0674(95)80088-3

Current Opinion in Cell Biology

Volume 7, Issue 3, 1995, Pages 337-343

https://doi.org/10.1016/0955-0674(95)80088-3 Get rights and content

Abstract

Specific proteinases of the Ced-3/interleukin-1β converting enzyme family trigger a multi-enzyme cascade that drives apoptotic events. Studies with newly developed cell-free systems have begun to identify the substrates of these and other proteinases in apoptosis. Studies with intact cells have revealed that cleavage of the genome into domain-sized fragments precedes the activation of a second nuclease that fragments the DNA into nucleosome-sized pieces.

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Nuclear changes in apoptosis

Abstract

Exp Cell Res

J Cell Biol

Cancer Res

J Biol Chem

J Immunol

EMBO J

Eur J Biochem

Cell

Cell

Genes Dev

Cell

Cell Growth Differ

J Cell Biol

Proc Natl Acad Sci USA

Cell death: the significance of apoptosis

Int Rev Cytol

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis

J Cell Biol

Genome digestion is a dispensible consequence of physiological cell death mediated by cytotoxic T lymphocytes

Mol Cell Biol

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note

Cancer Res

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

Cell

Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing

Int Immunol

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death

J Immunol

Apoptosis: the role of the endonuclease

Am J Pathol

Differential induction of apoptosis in undifferentiated and differentiated HL-60 cells by DAN topoisomerase I and II inhibitors

Blood

Programmed cell death and Bcl-2 protection in the absence of a nucleus

EMBO J

Mitotic chromatin condensation in vitro using somatic cell extracts and nuclei with variable levels of endogenous topoisomerase II

J Cell Biol

prICE, an ICE-like protease from apoptotic cells, cleaves poly (ADP-ribose) polymerase

Nature

Cell-free apoptosis in Xenopus EGG extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

Cell