Elsevier

Research in Immunology

Volume 146, Issues 4–5, May–June 1995, Pages 235-248
Research in Immunology

Natural autoantibodies: The other side of the immune system

https://doi.org/10.1016/0923-2494(96)80259-8Get rights and content

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      Following genetic recombination to create antibody diversity, those clones capable of autoreactivity are permanently deleted from the antibody repertoire (clonal selection and clonal deletion) [55]. Thus, the commonly held belief is that the presence of antibodies in serum capable of autoreactivity (autoantibodies) indicates an auto-immune (disease) state [56]. The presence of AKAs has been demonstrated in a range of human disease states [50,57], with IgG, IgA and IgM AKAs identified in normal human sera [45].

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      But further investigations proved that the phenomenon was widespread, involving antibodies that react to a multitude of intra- and extracellular autoantigens. These autoantibodies were identified in a variety of biological fluids, including blood, colostrum, saliva, and CSF (Avrameas, 1991; Avrameas & Ternynck, 1995; Bouvet & Dighiero, 1998). And they were identified in all tested mammals, including mice, rats, rabbits, pigs, and cows.

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