HIV and pulmonary immune responses

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Abstract

The lung is a central organ in human immunodeficiency virus (HIV)-induced pathophysiology, becoming infected during the asymptomatic period of the disease. The presence of HIV elicits a discrete virus-specific cytotoxic T lymphocyte (CTL)-mediated immune response in the pulmonary microenvironment. Here, Carlo Agostini and colleagues provide a framework for understanding the mechanisms underlying the spread of the retrovirus and the consequent progression of disease in patients with AIDS-associatcd lung involvement.

References (43)

  • AgostiniC. et al.

    Cell. Immunol.

    (1994)
  • DavisM.M. et al.

    Immunol. Today

    (1995)
  • SemenzatoG. et al.

    Blood

    (1995)
  • PabstR.

    Immunol. Today

    (1992)
  • DobrescuD. et al.

    Cell

    (1995)
  • AgostiniC. et al.

    Chest

    (1991)
  • SmithC.A. et al.

    Cell

    (1994)
  • ClericiM. et al.

    Immunol. Today

    (1993)
  • ThompsonC.B.

    Cell

    (1995)
  • DalgleishA.G.

    Immunol. Today

    (1995)
  • MitchellD.M. et al.

    Thorax

    (1995)
  • AgostiniC. et al.

    Am. Rev. Respir. Dis.

    (1993)
  • NewburyR.L. et al.

    Semin. Respir. Crit. Care Med.

    (1995)
  • AgostiniC. et al.

    Eur. Respir. J.

    (1993)
  • PlataF. et al.

    Nature

    (1987)
  • AgostiniC. et al.

    Am. Rev. Respir. Dis.

    (1990)
  • NishimuraH. et al.

    Eur. J. Immunol.

    (1995)
  • Sadat-SowtiB. et al.

    Am. J. Respir. Crit. Care Med.

    (1994)
  • PantaleoG. et al.

    Immunol. Rev.

    (1994)
  • ClarkeJ.R. et al.

    Thorax

    (1993)
  • PiatakM. et al.

    Science

    (1993)
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    The authors are supported by a grant from ministero della Satina,`Istituto Superiore di Satina (MS/ISS), Progetto AIDS 1995/1996 (Rome, Italy).

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