Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases

doi:10.1016/0167-5699(95)80068-9

Immunology Today

Volume 16, Issue 1, 1995, Pages 34-38

Immunology Today

https://doi.org/10.1016/0167-5699(95)80068-9 Get rights and content

Abstract

CD4⁺ T cells play a key role in regulating immune system function. When these regulatory processes go awry, organ-specific autoimmune diseases may develop. Here, Roland Liblau, Steven Singer and Hugh McDevitt explore the thesis that a particular subset of CD4⁺ T cells, namely T helper 1 (Th1) cells, contributes to the pathogenesis of organ-specifc autoimmune diseases, while another subset, Th2 cells, prevents them.

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^☆: We gratefully acknowledge Xiao-Dong Yang, Roland Tisch and Chris Goodnow for discussions and critical reading of the manuscript.

¹: Roland S. Liblau and Hugh O. McDevitt are at the Dept of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5402, USA; Steven M. Singer is at the Dept of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

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Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases☆

Abstract

Cell

Immunol. Today

J. Cell. Biochem.

J. Neuroimmunol.

J. Autoimmunity

J. Autoimmunity

Immunity

Annu. Rev. Immunol.

J. Immunol.

Eur. J. Immunol.

Endocrinology

Proc. Natl Acad. Sci. USA

J. Exp. Med.

J. Immunol.

J. Exp. Med.

J. Exp. Med.

Eur. J. Immunol.

Eur. J. Immunol.

Proc. Natl Acad. Sci. USA

Autoimmunity

Diabetes

Th1 and Th2 CD4⁺ T cells in the pathogenesis of organ-specific autoimmune diseases☆