review
CD40 ligand and its role in X-linked hyper-IgM syndrome

https://doi.org/10.1016/0167-5699(93)90188-QGet rights and content

Abstract

CD40 ligand (CD40L) on activated T cells binding to CD40 on B cells is of critical importance for Ig heavy-chain switching and rescue of B cells from apoptosis after somatic mutation in the germinal centre. Mutations in the CD40L gene are now known to cause X-linked hyper-IgM syndrome (HIGM1), an immunodeficiency characterized by the absence of serum IgG, IgA and IgE. In this review, we discuss how basic and clinical immunology have combined to provide major insights into the function of CD40 in T-B cell collaboration.

References (34)

  • R.J. Noelle et al.

    Immunol. Today

    (1992)
  • Y.-J. Liu et al.

    Immunol. Today

    (1992)
  • M. Padayachee et al.

    Genomics

    (1992)
  • A. Aruffo et al.

    Cell

    (1993)
  • G.N. Beall et al.

    J. Allergy Clin. Immunol.

    (1980)
  • S. Lederman et al.

    J. Immunol.

    (1992)
  • A.H. Gely et al.

    J. Immunol.

    (1992)
  • E.A. Clark

    Tissue Antigens

    (1990)
  • E.A. Clark et al.

    Eur. J. Immunol.

    (1988)
  • A. Valle et al.

    Eur. J. Immunol.

    (1989)
  • J.F. Gauchat et al.

    Int. Immunol.

    (1992)
  • H. Gascan et al.

    J. Immunol.

    (1991)
  • S.K. Shapira et al.

    J. Exp. Med.

    (1992)
  • Y.-J. Liu et al.

    Nature

    (1989)
  • R.J. Armitage et al.

    Nature

    (1992)
  • M.K. Springs et al.

    J. Exp. Med.

    (1992)
  • D. Hollenbaugh et al.

    EMBO J.

    (1992)
  • Cited by (0)

    View full text