Cell
ArticleDown-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction
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Induced pluripotent stem cells-derived myeloid-derived suppressor cells regulate the CD8 <sup>+</sup> T cell response
2018, Stem Cell ResearchCitation Excerpt :C57BL/6 (B6; H-2kb) and BALB/c (H-2kd) mice were purchased from Jackson Laboratory (Bar Harbor, ME). Hep-OVA transgenic (Tu et al., 2011), OT-I TCR transgenic (Hogquist et al., 1994), OT-II TCR transgenic (Barnden et al., 1998), and DES TCR transgenic (B10.BR) mice (Schonrich et al., 1991) (all transgenic mice were B6 background) were bred at the Lerner Research Institute and used at 10–12 weeks of age. All animals were maintained under specific pathogen-free conditions and in accordance with the National Institutes of Health guidelines.
Mechanisms of immunological tolerance
2016, Clinical BiochemistryTransfer of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance
2014, Journal of HepatologyCitation Excerpt :Therefore we used a transgenic mouse line with HSC-specific expression of the MHC-I H-2Kb gene under control of the GFAP promoter (GFAP-Kb). In GFAP-Kb mice, H-2Kb expression is observed in astrocytes within the central nervous system [21], enterocytes [19], and within the liver on GFAP-expressing quiescent HSC (Supplementary Fig. 1A). We did not detect H-2Kb expression on bone marrow-derived immune cells such as monocytes, macrophages, dendritic cells, B cells or T cells in spleen, lung, or kidney (Supplementary Fig. 1B and C), demonstrating that this transgenic mouse model can be used to study the antigen presenting cell function of HSCs within the liver in vivo.
Promotion and prevention of autoimmune disease by CD8+ T cells
2013, Journal of AutoimmunityHelper T cells down-regulate CD4 expression upon chronic stimulation giving rise to double-negative T cells
2013, Cellular ImmunologyCitation Excerpt :Thymic origin has been speculated to occur via escape of negative selection, followed by activation in the periphery [5,6]. Alternatively, because DNT cells are defined as CD3+CD4−CD8− cells, it has been hypothesized that they could arise in the periphery from CD4+ or CD8+ precursors [7,8]. Autoimmune lymphoproliferative syndrome (ALPS) results from defective lymphocyte apoptosis and is characterized by accumulation of DNT cells in the peripheral circulation and lymphoid tissues, as well as lymphadenopathy, splenomegaly, and autoimmunity [9].