Focal epithelial hyperplasia: Report of four cases in Mestizos from Cochabamba, Bolivia

doi:10.1016/0030-4220(69)90025-5

Oral Surgery, Oral Medicine, Oral Pathology

Volume 27, Issue 1, January 1969, Pages 15-19

Oral Surgery, Oral M...

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Abstract

Four cases of focal epithelial hyperplasia are described in mestizos from Cochabamba, Bolivia. No infectious process or dietary factor could be ascertained from the clinical history to explain the etiology of the lesions.

References (4)

H.O. Archard et al.
Focal Epithelial Hyperplasia an Unusual Oral Mucosal Lesion in Indian Children
Oral Surg., Oral Med. & Oral Path
(1965)
C.J. Witkop et al.
Focal Epithelial Hyperplasia in Central and South American Indians and Ladinos
Oral Surg., Oral Med. & Oral Path
(1965)

There are more references available in the full text version of this article.

Cited by (23)

Molecular and serological evidence of the epidemiological association of HPV 13 with focal epithelial hyperplasia: A case-control study
2006, Journal of Clinical Virology
Focal epithelial hyperplasia is a benign proliferative condition that is more frequently found in children of certain ethnic groups. Human papillomavirus 13 and 32 DNA has been consistently detected in these lesions.
To demonstrate the epidemiological association of HPV 13 with FEH in the Emberá-Chamí community of Antioquia, Colombia.
A population-based, case-control study was conducted. One hundred and thirty-eight children were screened and 17 clinical and histologically-confirmed cases were sex and age-matched with 27 controls. Biopsies from FEH lesions and mouth washes from controls were obtained for DNA analysis. HPV 13 DNA was identified using a previously described type-specific PCR test. HPV 13 VLPs were produced by cloning of L1 from the HPV 13 cloned genome and seroreactivity against HPV 13 VLPs of sera from cases and controls were evaluated by ELISA.
Among the whole population the prevalence of FEH was 13%. One-hundred-percent of the cases and 29.6% of the controls were HPV 13 positive. There was a significant difference in HPV DNA status between cases and controls (one-tailed Fisher exact test: P < 0.0001). Antibodies against HPV 13 VLPs were found in 58.8% of cases and in 33.3% of controls, this difference was not statistically significant (P = 0.089 Fisher exact test). However, the median of the ODs of the ELISA positive sera of the cases was 0.596 (interquartile range: 0.5075–0.8245) versus 0.452 (interquartile range: 0.337–0.479) in the controls and this was significantly different (P = 0.0041 Man–Whitney test).
We demonstrated a risk for association of FEH with infection with HPV 13. The higher level of antibodies against HPV 13 VLPs in cases may suggest the requirement of higher viral load or viral persistence for disease development.
Focal epithelial hyperplasia. Report of three cases from Nigeria, West Africa
1983, Oral Surgery, Oral Medicine, Oral Pathology
The first cases of focal epithelial hyperplasia from Nigeria and West Africa are presented. Although cases of this disease have been reported in Coloureds from South Africa, the three cases in this report represent the first in black Africans. The probability that the etiologic agent is a communicable agent, perhaps a virus, is reinforced by the clinical histories of the two related patients in this report.
Focal epithelial hyperplasia
1981, Oral Surgery, Oral Medicine, Oral Pathology
Focal epithelial hyperplasia. Report of five new cases from Argentina
1975, Oral Surgery, Oral Medicine, Oral Pathology
Focal epithelial hyperplasia in an Israeli family
1973, Oral Surgery, Oral Medicine, Oral Pathology
Occurrence of focal epithelial hyperplasia among Amerindians in Ecuador
1973, International Journal of Oral Surgery
The prevalence of focal epithelial hyperplasia in two small groups of Amerindians in Ecuador has been studied. All age groups were examined. Among 65 Cofanes Amerindians in Dureno, no cases of the disease could be diagnosed, At Huino, 125 Quichuas Amerindians were examined, and three cases of focal epithelial hyperplasia were found in two boys (9 and 12 years old) and a 15-year-old girl. Biopsies from all three patients verified the diagnosis. The prevalence among Quichuas Amerindians was 2.4 %.

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^∗: From the Department of Pathology, Faculty of Medicine (P.O. Box 1173).

^∗∗: From the Division of Clinical Oral Pathology, Faculty of Dentistry, (P.O. Box 858).

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Focal epithelial hyperplasia: Report of four cases in Mestizos from Cochabamba, Bolivia

Abstract

Oral Surg., Oral Med. & Oral Path

Oral Surg., Oral Med. & Oral Path