Cartilage matrix metabolism in osteoarthritis: markers in synovial fluid, serum, and urine
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Relationship between weight loss in obese knee osteoarthritis patients and serum biomarkers of cartilage breakdown: secondary analyses of a randomised trial
2017, Osteoarthritis and CartilageCitation Excerpt :Loss of cartilage is a cardinal feature of knee osteoarthritis (KOA)1, and disease-modifying treatment still needs to be identified.
Effect of a 16 weeks weight loss program on osteoarthritis biomarkers in obese patients with knee osteoarthritis: A prospective cohort study
2014, Osteoarthritis and CartilageCitation Excerpt :Knee osteoarthritis (KOA) is characterized by loss of articular cartilage1,2 with changes in thickness, water content and mechanical properties3, as well as changes in the subchondral bone and osteophyte formation4. Cartilage biomarkers may be used to describe the degenerative status and prospectively assess metabolic processes of the joint1,5. Among these markers, Cartilage Oligomeric Matrix Protein (COMP) concentration in blood is a possible candidate to indicate pathological turnover of cartilage at early stages of arthritis, preceding ensuing structural breakdown of cartilage visible on radiography6–8, since COMP is suggested to participate in the forming and maintenance of the cartilage matrix9,10.
Association of plasma and synovial fluid interferon-γ inducible protein-10 with radiographic severity in knee osteoarthritis
2011, Clinical BiochemistryCitation Excerpt :Additionally, circulating levels of TNF-α and IL-6 were associated with radiographic knee osteoarthritis and knee cartilage loss, suggesting that low level inflammation may play a role in the pathogenesis of knee OA [32]. In addition to inflammatory mediators, breakdown of articular cartilage matrix during OA leads to the generation of constituent fragments that may serve as biochemical markers of OA [2]. Cartilage oligomeric matrix protein (COMP), a member of the thrombospondin family of glycoproteins, has been proposed as a molecular marker of cartilage degradation in OA [33].
Osteoarthritis: An overview of the disease and its treatment strategies
2005, Seminars in Arthritis and RheumatismCitation Excerpt :The pathological characteristics of OA are loss of cartilage with associated underlying bony changes consisting of sclerosis, subchondral bone collapse, bone cysts, and osteophyte formation (10). The loss of articular cartilage in OA may start as a focal lesion and progressively extend to involve specific joint compartments, thus inducing alterations in articulating surfaces (11) and leading to progressive loss of cartilage (12). Superficial fibrillation is associated with the loss of the small proteoglycans, decorin, and biglycan, which are usually closely associated with the fibrils at the articular surface (13), and the large proteoglycan aggrecan (14).
Articular cartilage metabolism: Biochemical markers and dynamic loading
2020, Articular Cartilage of the Knee: Health, Disease and TherapyMMP-3 in the peripheral serum as a biomarker of knee osteoarthritis, 40 years after open total knee meniscectomy
2018, Journal of Experimental Orthopaedics