Osteolytic paget's bone disease in a young man. Rapid healing with human calcitonin therapy

doi:10.1016/0002-9343(85)90444-9

The American Journal of Medicine

Volume 78, Issue 2, February 1985, Pages 326-332

https://doi.org/10.1016/0002-9343(85)90444-9 Get rights and content

Abstract

Paget's bone disease is rare in young adults. Severe osteolytic Paget's bone disease In a 28-year-old man was found to respond, clinically, biochemically, and radiographically, within one month to daily subcutaneous injections of 0.5 mg of synthetic human calcitonin. After two years of therapy, he remains asymptomatic and has no biochemical evidence of Paget's bone disease while receiving Injections three times a week. Despite aggressive disease, young patients may rapidly demonstrate the same beneficial response to synthetic human calcitonin therapy as has been observed in middle-aged or elderly patients with Paget's bone disease.

References (14)

RC Thompson et al.
Hereditary hyperphosphatasia
HC Barry
Paget's disease of bone
RC Hamdy
Paget's disease of bone
FH Doyle et al.
Healing of bones in juvenile Paget's disease treated by human calcitonin
Br J Radiol
(1974)
M Horwith et al.
Hereditary bone dysplasia with hyperphosphatasemia: response to synthetic human calcitonin
Clin Endocrinol
(1976)
PH Henneman et al.
Effects of aspirin and corticosteroids on Paget's disease of bone
Trans Stud Coll Physicians Phila
(1963)
C Nagant de Deuxchaisnes et al.
Roentgenologic evaluation of the efficacy of calcitonin in Paget's disease of bone

There are more references available in the full text version of this article.

Cited by (15)

Paget's disease of bone: A rare case in a patient under 40 years of age
2021, Human Pathology Reports
Paget’s disease of bone is a rare diagnosis in patients under 40 years of age. We report a case diagnosed in a 35-year-old patient with suspected symptomatic presentation at the age of 30 years during pregnancy. This report details the course of the patient’s evaluation toward diagnosis and includes previously suspected etiologies, significant radiologic features and conclusive histologic findings. This case is relevant to the existing literature because it demonstrates that Paget’s disease of bone should be included in the differential diagnosis of younger patients outside the traditional disease demographic who present with diagnostic radiologic findings and elevated serum alkaline phosphatase.
Asymptomatic paget's bone disease in the young adult
2006, Revista Espanola de Enfermedades Metabolicas Oseas
Presentamos el caso clínico de un varón de 39 años, diagnosticado de enfermedad ósea de Paget, con afectación ósea craneal y aumento de fosfatasa alcalina sérica e isoenzima ósea.
Se realiza revisión de las escasas publicaciones de la enfermedad de Paget en el adulto joven y se sugiere la necesidad de seguir clínicamente cohortes de pacientes con edad de inicio inferior a 40 años.
We discussed the case of a 39 years old man, diagnosed with Paget's bone disease, with cranial bone affection and raised levels in serum alkaline phosphatase and their bone isoenzyme. We present a review of a few published cases about Paget's bone disease in early adult life and we suggest to need follow-up cohorts of Paget's bone disease with early adult onset lower than 40 years.
Bone Paget's disease in the young adult
2004, Revista Clinica Espanola
La enfermedad ósea de Paget es un trastorno focal del remodelado óseo, de etiología desconocida, que afecta principalmente a los mayores de 50 años. Es la osteopatía más frecuente del mundo occidental después de la osteoporosis. Fue descrita por primera vez en 1876 por Sir James Paget con el nombre de «osteítis deformante».
Presentamos dos casos con enfermedad ósea de Paget con edad inferior a los 40 años. Se describen sus características clínicas, analíticas, diagnósticas y terapéuticas con realización de biopsia ósea en uno de ellos. Nos llama la atención la edad de aparición poco habitual de la enfermedad, por lo que hemos realizado un seguimiento de los casos. Conclusión. Ante unas cifras elevadas de la fosfatasa alcalina en un adulto joven, incluiremos en el diagnóstico diferencial la enfermedad ósea de Paget.
Bone Paget's disease (BPD) is a focal disorder of bone remodeling of unknown etiology that affects mainly patients older than 50 years. BPD is after osteoporosis the most frequent osteopathy of the western world and was described for the first time in 1876 by Sir James Paget who called it «osteitis deformans».
We present two patients with BPD younger than 40 years. In this report their clinical, analytical, diagnostic, and therapeutic manifestations are described, with the findings of bone biopsy in one of them. Is noteworthy to us the younger age of the patients, rare for this disease, which means that we have carried out the follow-up of the cases.
In a young adult with high phosphatase alkaline values we will include BPD in the differential diagnosis.
Bone Paget's disease in the young adult
2004, Revista Clinica Espanola
Paget's disease of the bone
1994, Clinics in Geriatric Medicine
Southwestern Internal Medicine Conference: Paget's disease of bone
1988, American Journal of the Medical Sciences
Paget’s disease is a relatively common bone disease. This review aims to present reasonable treatment recommendations with enough background to understand them. To accomplish this end, some aspects of basic bone cell biology, biochemistry, and pathology are presented, as are speculations about possible causes of this disease. Treatment of Paget’s disease will be considered in three sections. The first two sections will review treatment with calcitonin and diphosphonates, respectively. These sections briefly will consider the mechanism of action of the drugs, review in detail clinical studies of drug effectiveness, and summarize the advantages and disadvantages of each drug. The third section details specific treatment recommendations for each of the six clinical settings in which treatment of Paget’s disease is justified.

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^☆: This work was supported in part by Grant RR-00036 from the General Clinical Research Center Branch, Division of Research Facilities and Resources, National Institutes of Health, and by a grant-in-aid from the Shriners Hospitals for Crippled Children (St. Louis Unit).

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Case reportOsteolytic paget's bone disease in a young man. Rapid healing with human calcitonin therapy☆

Abstract

Paget's disease of bone

Paget's disease of bone

Healing of bones in juvenile Paget's disease treated by human calcitonin

Br J Radiol

Hereditary bone dysplasia with hyperphosphatasemia: response to synthetic human calcitonin

Clin Endocrinol

Effects of aspirin and corticosteroids on Paget's disease of bone

Trans Stud Coll Physicians Phila

Roentgenologic evaluation of the efficacy of calcitonin in Paget's disease of bone

Case report
Osteolytic paget's bone disease in a young man. Rapid healing with human calcitonin therapy☆