Clinical studyEffects of food, fast and alcohol on serum uric acid and acute attacks of gout☆
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Association of variability in uric acid and future clinical outcomes of patient with coronary artery disease undergoing percutaneous coronary intervention
2020, AtherosclerosisCitation Excerpt :Rats with hyperuricemia induced with an uricase inhibitor showed increased oxidative stress and developed hypertension that could be blocked by antioxidant treatment [21,22]. In addition, UA crystals can induce an inflammatory response by stimulating the release of chemokines (e.g., monocyte chemoattractant protein-1, MCP-1), inflammatory markers (e.g., high-sensitivity C-reactive protein), and the activation of vasoconstrictive mediators (e.g., thromboxane, endothelin-1 and angiotensin II) [22,23]. Furthermore, hyperuricemia is proven to cause endothelial dysfunction in humans by reducing NO bioavailability [24–26] and the use of UA-lowering agents improves endothelial function [27,28].
Clinical pathologic conference: acute onset malocclusion and facial pain
2018, Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyCitation Excerpt :Given the patient's clinical history of gout on her left toes and the presentation of pain and swelling of the temporomandibular joint, recurrent gout was given consideration due to potential for hyperuricemia. Gout, also known as monosodium urate crystal deposition disease, is characterized by a saturation of urate crystals in the extracellular fluid.2 Acute gout is evidenced by the presence of these crystals in the synovial fluid of joints, which may be aspirated for analysis.
Nutrition and Rheumatic Diseases
2016, Kelley and Firestein's Textbook of Rheumatology: Volumes 1-2, Tenth EditionGout: A review of nonmodifiable and modifiable risk factors
2014, Rheumatic Disease Clinics of North AmericaCitation Excerpt :Since antiquity, alcohol consumption has been linked to gout. More formal research from the 1960s demonstrated that alcohol administration caused decreased uric acid excretion and hyperuricemia.61 Ethanol ingestion increases serum lactate levels, which inhibit uric acid excretion at the renal tubule; however, this has not been confirmed in subsequent studies.62
Diet, alcohol, obesity, hyperuricemia, and risk of gout
2012, Gout and Other Crystal ArthropathiesNutrition and Rheumatic Diseases
2012, Kelley's Textbook of Rheumatology: Volume 1-2, Ninth Edition
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This study was supported by a Graduate Training Grant in Arthritis and Rheumatism (2A-5031), USPHS Grant 5 MO1 FR-00056, and a grant from the Health Research and Services Foundation of Allegheny County. It was presented, in part, at the Annual Meeting of the American Rheumatism Association, June 17, 1965, and reported in abstract form [1].
- 1
From the Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.