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Evaluation of Synovial Inflammation in Juvenile Idiopathic Arthritis by Power Color Doppler and Spectral Doppler Ultrasonography

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Abstract

Objectives

To compare Power Color Doppler and Spectral Doppler ultrasonography indices (Resistive index and color fraction) in cases of Juvenile Idiopathic Arthritis (JIA) with healthy controls and evaluate their correlation with clinical and laboratory parameters.

Methods

A cross sectional study was done over a period of 16 mo. Thirty patients of JIA and 30 age and sex matched healthy children were enrolled. Swelling and tenderness scores were evaluated and hemoglobin, total leukocyte count, erythrocyte sedimentation rate and C-reactive protein were done. A total of 112 diseased joints and 135 healthy joints were evaluated by USG by the same radiologist, and color fraction and RI were recorded.

Results

Statistically significant higher color fraction and lower RI (Resistive Index) were found in diseased joints as compared to healthy joints. Also the value of color fraction increased significantly with increasing grade of tenderness and RI decreased significantly with increasing grade of swelling.

Conclusions

Power Color Doppler and Spectral Doppler ultrasonography (USG) indices (RI and color fraction) are significantly different in JIA patients. These might find a place in early diagnosis, monitoring of disease activity and response to therapy in JIA patients.

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Acknowledgments

The authors acknowledge the help provided by Dr Dinesh Sethi for calculating color pixels and total pixels in adobe Photoshop.

Contributions

TPY, SR, NS: Conceptualized the study and collected, analyzed and interpreted the data; TPY, NS, SR, AJ, SS: Interpreted the data and drafted the manuscript; TPY, VD, NS: Critically evaluated the manuscript to its final shape.

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None.

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Authors and Affiliations

  1. Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Dr. Ram Manohar Lohia Hospital, New Delhi, India

    Sanjeev Ranjan, Afsana Jahan, Tribhuvan Pal Yadav, Vivek Dewan & Shweta Singh

  2. H 1571 GF, Chittaranjan Park, New Delhi, 110019, India

    Tribhuvan Pal Yadav

  3. Department of Radiology, Post Graduate Institute of Medical Education and Research, Dr. Ram Manohar Lohia Hospital, New Delhi, India

    Namrita Sachdev

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  1. Sanjeev Ranjan
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  2. Afsana Jahan
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  3. Tribhuvan Pal Yadav
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  5. Vivek Dewan
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  6. Shweta Singh
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Correspondence to Tribhuvan Pal Yadav.

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Ranjan, S., Jahan, A., Yadav, T.P. et al. Evaluation of Synovial Inflammation in Juvenile Idiopathic Arthritis by Power Color Doppler and Spectral Doppler Ultrasonography. Indian J Pediatr 81, 29–35 (2014). https://doi.org/10.1007/s12098-013-1085-9

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  • DOI: https://doi.org/10.1007/s12098-013-1085-9

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