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T cells in psoriatic arthritis

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Abstract

Psoriatic arthritis is characterized by chronic inflammation of the skin and synovial joint. T cells are abundant in the inflamed joint and skin. Disease susceptibility is associated with major histocompatibility complex, which presents antigens to T cells. T cells in the synovial joints have an activated phenotype and demonstrate selective T-cell receptor usage suggestive of oligoclonal expansions. Taken together, these facts suggest that psoriatic arthritis is driven by antigen or autoantigen-driven T-cell activation. The therapeutic benefit of anti-T-cell agents further supports an important pathogenic role for T cells in persistent synovial inflammation and joint damage in psoriatic arthritis.

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  1. Academic Department of Rheumatology, King’s College London, Weston Education Center, Cutcombe Road, London, SE5 9PJ, UK

    Ernest Choy

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  1. Ernest Choy
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Correspondence to Ernest Choy.

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Choy, E. T cells in psoriatic arthritis. Curr Rheumatol Rep 9, 437–441 (2007). https://doi.org/10.1007/s11926-007-0071-5

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  • DOI: https://doi.org/10.1007/s11926-007-0071-5

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