Abstract
We examined the components of metabolic syndrome associated with gout in different age strata by a large-scale case-controlled study. Totally, 12,179 gouty subjects were divided into three groups according to their ages at first visit: young- (19–44 years), middle- (45–64 years), and old-aged (≥65 years) groups. Their clinical and laboratory data, as well as the risk of gout by the metabolic syndrome, were analyzed in three age groups and compared with a control population. The numbers of the cases in the young-, middle-, and old-aged groups in the gout population were 4,698, 4,847, and 2,634, respectively. The serum urate level and the percentage of positive family history of gout were the highest in young-aged group and declined with increasing age. When compared with the data of the control population, the incidence of overweight (body mass index, ≥24.2 kg/m2) and hypertriglyceridemia (triglyceride, ≥2.26 mmol/l) were significantly higher in the gout population for all age groups. The incidence of type 2 diabetes was significantly higher in the gout as well for all age groups, and the odds ratio was highest in the young-aged group [odds ratio (95% confidence interval), 5.55 (3.05–10.09)]. In all, except for the old-aged groups, the incidence of hypercholesterolemia was significantly higher in the gout than in the control population, whereas the incidence of hypertension was significantly higher in the gout than in the control population only in the old-aged group. Various clinical and laboratory data were suggested to be the risks of gout in different degrees between age strata.
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References
Chang HY, Pan WH, Yeh WT, Tsai KS (2001) Hyperuricaemia and gout in Taiwan: results from the nutritional and health survey in Taiwan (1993–1996). J Rheumatol 28(7):1640–1646
Mikuls TR, Farrar JT, Bilker WB, Fernandes S, Schumacher HR Jr, Saag KG (2005) Gout epidemiology: results from the UK general practice research database, 1990–1999. Ann Rheum Dis 64:267–272
Harris C, Lloyd C, Lewis J (1995) The prevalence and prophylaxis of gout in England. J Clin Epidemiol 48:1153–1158
Chen SY, Chen CL, Shen ML, Kamatani N (2003) Trends in the clinical manifestations of gout in Taiwan. Rheumatology 42(12):1529–1533
Kelley WN, Schumacher HR Jr (1993) Gout. In: Kelley WN, Harris ED Jr, Ruddy S, Sledge CB (eds) Textbook of rheumatology, 4th edn. Saunders, Philadelphia, pp 1291–1336
Chen CL, Kamatani N, Nishioka K, Mikanagi K (1989) Clinical aspects of gouty patients in Taiwan. Adv Exp Med Biol 253A:189–195
DeFronzo RA, Ferrannini E (1991) Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia, and atherosclerotic cardiovascular disease. Diabetes Care 14:173–194
Facchini F, Chen YD, Hollenbeck CB, Reaven GM (1991) Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. JAMA 266(21):3008–3011
Quinones Galvan A, Natali A, Baldi S, Frascerra S, Sanna G, Ciociaro D et al (1995) Effect of insulin on uric acid excretion in humans. Am J Physiol 268(1 Pt 1):E1–E5
Lin K, Lin H, Chou P (2000) Community based epidemiological study on hyperuricemia and gout in Kin-Hu, Kinmen. J Rheumatol 27:1045–1050
Wallace SL, Robinson H, Masi AT, Decher JL, McCarty DJ, Yu TF (1977) Preliminary criteria for the classification of the acute arthritis of primary gout. Arthritis Rheum 20:895–900
Department of Health, Taiwan (1999) Nutrition and health survey in Taiwan (1993–1996) [in Chinese]. Department of Health, Taiwan
Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15:539–553
1988 Joint National Committee (1988) The 1988 report of the joint national committee on detection, evaluation and treatment of high blood pressure. Arch Intern Med 148:1023–1038
Choi HK, Atkinson K, Karlson EW, Willett W, Curhan G (2004) Alcohol intake and risk of incident gout in men: a prospective study. Lancet 363:1277–1281
Denke M, Wilson JD (1998) Assessment of nutritional status. In: Isselbacher KJ, Braunwald E, Wilson JD, Martin JB, Fauci AS, Kasper DL (eds) Harrison’s principles of internal medicine, 14th edn. McGraw-Hill, New York, pp 448–452
Pan WH, Flegal KM, Chang HY, Yeh WT, Yeh CJ, Lee WC (2004) Body mass index and obesity-related metabolic disorders in Taiwanese and US whites and blacks: implications for definitions of overweight and obesity for Asians. Am J Clin Nutr 79(1):31–39
Lyu LC, Hsu CY, Yeh CY, Lee MS, Huang SH, Chen CL (2003) A case-control study of the association of diet and obesity with gout in Taiwan. Am J Clin Nutr 78:690–701
Chen SY, Chen CL, Shen ML, Kamatani N (2001) Clinical features of familial gout and effects of probable genetic linkage between gout and its associated metabolic disorders. Metabolism 50(10):1203–1207
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The authors would like to thank the Department of Health in Taiwan for providing the data of the general population from the national health survey.
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Chen, SY., Chen, CL. & Shen, ML. Manifestations of metabolic syndrome associated with male gout in different age strata. Clin Rheumatol 26, 1453–1457 (2007). https://doi.org/10.1007/s10067-006-0527-4
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DOI: https://doi.org/10.1007/s10067-006-0527-4