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Hepatitis C virus infection and mutations of mannose-binding lectin gene MBL

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Summary

We assessed the genetic polymorphism of mannose-binding lectin (MBL) in 93 patients with chronic hepatitis C (45 responders and 48 nonresponders to interferon) and 218 healthy controls. Mutant allele was identified only at codon 54 (Gly→Asp), leading to three genotypes (54 m/m, 54 W/m, and 54 W/W). Frequency of 54 m/m was significantly lower in interferon-responders (2.2%) compared to those in nonresponders (14.6%) and controls (10.6%): p<0.05. Our results suggest that homozygous carriage of the variant allele of codon 54 of MBL may predict poor response to interferon in chronic hepatitis C patients.

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Authors and Affiliations

  1. Department of Medical Sciences, Toshiba General Hospital, Tokyo, Japan, Japan

    M. Matsushita, M. Hijikata & S. Mishiro

  2. Department of Internal Medicine, Toshiba General Hospital, Tokyo, Japan, Japan

    Y. Ohta, K. Iwata, M. Matsumoto, K. Nakao & K. Kanai

  3. Multiphasic Health Screening Center, Toshiba General Hospital, Tokyo, Japan, Japan

    N. Yoshida

  4. Central Clinical Laboratory, Toshiba General Hospital, Tokyo, Japan, Japan

    K. Baba

Authors
  1. M. Matsushita
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  2. M. Hijikata
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  3. Y. Ohta
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  4. K. Iwata
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  5. M. Matsumoto
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  6. K. Nakao
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  7. K. Kanai
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  8. N. Yoshida
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  9. K. Baba
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  10. S. Mishiro
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Additional information

Accepted December 4, 1997 Received November 25, 1997

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Matsushita, M., Hijikata, M., Ohta, Y. et al. Hepatitis C virus infection and mutations of mannose-binding lectin gene MBL. Arch. Virol. 143, 645–651 (1998). https://doi.org/10.1007/s007050050320

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  • DOI: https://doi.org/10.1007/s007050050320

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