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The effect of strontium ranelate on serum insulin like growth factor-1 and leptin levels in osteoporotic post-menopausal women: a prospective study

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Abstract

Objective

The aim of this study was to investigate the effects of strontium ranelate on insulin like growth factor-1 (IGF-1), leptin and osteocalcin levels in osteoporotic post-menopausal women.

Study design

Thirty-three women were given 2 g/day strontium ranelate for 6 months. Serum IGF-1, leptin and osteocalcin levels were measured before and after the treatment.

Results

Strontium ranelate treatment increased IGF-1 levels significantly (P = 0.02). Leptin and osteocalcin levels did not change significantly before and after the treatment. There was no correlation between basal and 6-months treatment levels of IGF-1 and leptin.

Conclusion

Strontium ranelate increases serum IGF-1 levels in osteoporotic post-menopausal women.

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Acknowledgments

This research is supported by the Servier Pharmaceutical Company.

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Correspondence to Ibrahim Gulhan.

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Gulhan, I., Bilgili, S., Gunaydin, R. et al. The effect of strontium ranelate on serum insulin like growth factor-1 and leptin levels in osteoporotic post-menopausal women: a prospective study. Arch Gynecol Obstet 278, 437–441 (2008). https://doi.org/10.1007/s00404-008-0611-x

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  • DOI: https://doi.org/10.1007/s00404-008-0611-x

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