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Vasoactive intestinal peptide

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References

  1. Said S.I., Mutt V. Polypeptide with broad biological activity: Isolation from small intestine. Science 169: 1217, 1970.

    PubMed  CAS  Google Scholar 

  2. Said S.I., Rosenberg R.N. Vasoactive intestinal polypeptide: abundant immunoreactivity in neural cell lines and normal nervous tissues. Science 192: 907, 1976.

    PubMed  CAS  Google Scholar 

  3. Fahrenkrug J. VIP as a neurotransmitter in the peripheral nervous system. In: Said S.I. (Ed.), Vasoactive intestinal peptide. Raven Press, New York, 1982, p. 361.

    Google Scholar 

  4. Marley P., Emson P. VIP as a neurotransmitter in the central nervous system. In: Said S.I. (Ed.), Vasoactive intestinal peptide. Raven Press, New York, 1982, p. 341.

    Google Scholar 

  5. Said S.I. Vasoactive intestinal polypeptide (VIP): Current status. Peptides 5: 143, 1984.

    PubMed  CAS  Google Scholar 

  6. Said S.I., Mutt V. Isolation from porcine intestinal wall of a vasoactive octacosapeptide related to secretin and to glucagon. Eur. J. Biochem. 28: 199, 1972.

    PubMed  CAS  Google Scholar 

  7. Tatemoto K. PHI-A new brain-gut peptide. Peptides 5: 151, 1984.

    PubMed  CAS  Google Scholar 

  8. Vale W., Spiess J., Rivier C., Rivier J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and B-endorphin. Science 213: 1394, 1981.

    PubMed  CAS  Google Scholar 

  9. Guillemin R., Brazeau P., Bohlen P., Esch F., Ling N., Wehrenberg W.B. Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly. Science 218: 585, 1982.

    PubMed  CAS  Google Scholar 

  10. Erspamer V., Falconieri Erspamer G., Improta G., Negri L., De Castiglione R. Sauvagine, a new polypeptide from phyllomedusa sauvagei skin. Occurrence in various phyllomedusa species and pharmacological actions on rat blood pressure and diuresis. Naunyn-Schmiedebergs Arch. Pharmacol. 312: 265, 1980.

    PubMed  CAS  Google Scholar 

  11. Lederis K., Letter A., McMaster D., Moore G., Schlesinger D. Complete amino acid sequence of urotensin I, a hypotensive and corticotropin-releasing neuropeptide from catostomus. Science 218: 162, 1982.

    PubMed  CAS  Google Scholar 

  12. Hoshino M., Yanaihara C., Hong Y.M., Kishida S., Katsumaru Y., Vandermeers A., Vandermeers-Piret M.C., Robberecht P., Christophe J., Yanaihara N. Primary structure of helodermin, a VIP-secretin-like peptide isolated from Gila monster venom. FEBS Lett. 178: 233, 1984.

    PubMed  CAS  Google Scholar 

  13. Yamaguchi K., Abe K. Macromolecular forms of VIP in VIP-secreting tumors. In: Said S.I. (Ed.), Vasoactive intestinal peptide. Raven Press, New York, 1982, p. 469.

    Google Scholar 

  14. Obata K.-I., Itoh N., Okamoto H., Yanaihara C., Yanaihara N., Suzuki T. Identification and processing of biosynthetic precursors to vasoactive intestinal polypeptide in human neuroblastoma cells. FEBS Lett. 136: 123, 1981.

    PubMed  CAS  Google Scholar 

  15. Itoh N., Obata K., Yanaihara N., Okamoto H. Human prepro-vasoactive intestinal polypeptide (VIP) mRNA contains the coding sequence for a novel PHI-27 like peptide, PHM-27. Nature 304: 547, 1983.

    PubMed  CAS  Google Scholar 

  16. Gozes I., Bodner M., Shani Y., Fridkin M. Structure arid expression of the vasoactive intestinal peptide (VIP) gene in a human tumor. Peptides 1986, in press.

  17. Bodner M., Fridkin M., Gozes I. Coding sequences for vasoactive intestinal peptide and PHM-27 peptide are located on two adjacent exons in the human genome. Proc. Natl. Acad. Sci. USA 82: 3548, 1985.

    PubMed Central  PubMed  CAS  Google Scholar 

  18. Mutt V. Isolation and structure of vasoactive intestinal polypeptide from various species. In: Said S.I. (Ed.), Vasoactive intestinal peptide. Raven Press, New York, 1982, p. 1.

    Google Scholar 

  19. Carlquist M., Mutt V., Jörnvall H. Isolation and characterization of bovine vasoactive intestinal peptide (VIP). FEBS Lett. 108: 457, 1979.

    PubMed  CAS  Google Scholar 

  20. Dimaline R., Reeve Jr. J.R., Shively J.E., Hawke D. Isolation and characterization of rat vasoactive intestinal peptide. Peptide 5: 183, 1984.

    CAS  Google Scholar 

  21. Du B.-H., Eng J., Hulmes J.D., Chang M., Pan Y.-C.E., Yalow R.S. Guinea pig has a unique mammalian VIP. Biochem. Biophys. Res. Commun. 128: 1093, 1985.

    PubMed  CAS  Google Scholar 

  22. Nilsson A. Structure of the vasoactive intestinal octacosapeptide from chicken intestine. The amino acid sequence. FEBS Lett. 60: 322, 1975.

    PubMed  CAS  Google Scholar 

  23. Giachetti A., Said S.I., Reynolds R.C., Koniges F.C. Vasoactive intestinal polypeptide (VIP) in brain: localization in, and release from isolated nerve terminals. Proc. Natl. Acad. Sci. USA 74: 3424, 1977.

    PubMed Central  PubMed  CAS  Google Scholar 

  24. Magistretti P.J., Morrison J.H., Shoemaker W.J., Sapin V., Bloom F.E. Vasoactive intestinal polypeptide induces glycogenolysis in mouse control of energy metabolism. Proc. Natl. Acad. Sci. USA 78: 6535, 1981.

    PubMed Central  PubMed  CAS  Google Scholar 

  25. Johansson O., Lundberg J.M. Ultrastructural localization of VIP-like immunoreactivity in large dense-core vesicles of “cholinergic-type” nerve terminals in cat exocrine glands. Neuroscience 6: 847, 1981.

    PubMed  CAS  Google Scholar 

  26. Morrison J.H., Magistretti P.J., Benoit R., Bloom F.E. The distribution and morphological characteristics of the intracortical VIP-positive cell: An immunohistochemical analysis. Brain Res. 292: 269, 1984.

    PubMed  CAS  Google Scholar 

  27. Loren I., Emson P.C., Fahrenkrug J., Björklund A., Alurnents J., Håkanson R., Sundler F. Distribution of vasoactive intestinal polypeptide in the rat and mouse brain. Neuroscience 4: 1953, 1979.

    PubMed  CAS  Google Scholar 

  28. Sims K.B., Hoffman D.L., Said S.I., Zimmerman E.A. Vasoactive intestinal polypeptide (VIP) in mouse and rat brain: An immunocytochemical study. Brain Res. 186: 165, 1980.

    PubMed  CAS  Google Scholar 

  29. Honda C.N., Rethelyi M., Petrusz P. Preferential immunohistochemical localization of vasoactive intestinal polypeptide (VIP) in the sacral spinal cord of the cat: light and electron microscopic observations. Neuroscience 3: 2183, 1983.

    PubMed  CAS  Google Scholar 

  30. Hökfelt T., Schultzhberg M., Lundberg J.M., Fuxe J., Mutt V., Fahrenkrug J., Said S.I. Distribution of vasoactive intestinal polypeptide in the central and peripheral nervous systems as revealed by immunocytochemistry. In: Said S.I. (Ed.), Vasoactive intestinal peptide. Raven Press, New York, 1982, p. 65.

    Google Scholar 

  31. Lundberg J.M., Hökfelt T., Schultzberg M., Uvnäs-Wallensten K., Kohler C., Said S.I. Occurrence of vasoactive intestinal polypeptide (VIP)-like immunoreactivity in certain cholinergic neurons of the cat: Evidence from combined immundhistochemistry and acetylcholine esterase staining. Neuroscience 4: 1539, 1979.

    PubMed  CAS  Google Scholar 

  32. Edvinsson L Functional role of perivascular peptides in the control of cerebral circulation. Trends in Neurosciences 8: 126, 1985.

    CAS  Google Scholar 

  33. Costa M., Furness J.B. The origins, pathways and terminations of neurons with VIP-like immunoreactivity in the guinea-pig small intestine. Neuroscience 8: 665, 1983.

    PubMed  CAS  Google Scholar 

  34. Weihe E., Reinecke M. Peptidergic innervation of the mammalian sinus nodes: Vasoactive intestinal polypeptide, neurotensin, substance P. Neurosci. Lett. 26: 283, 1981.

    PubMed  CAS  Google Scholar 

  35. Dey R.D., Shannon W.A., Said S.I. Localization of VIP-immunoreactive nerves in airways and pulmonary vessels of dogs, cats and human subjects. Cell Tissue Res. 220: 231, 1981.

    PubMed  CAS  Google Scholar 

  36. Ottesen G., Larsen J.-J., Fahrenkrug J., Stjernquist M., Sundler F. Distribution and motor effect of VIP in female genital tract. Am. J. Physiol. 240: E32, 1981.

    PubMed  CAS  Google Scholar 

  37. Terubayashi H., Tsuto T., Fukui K., Obata H.L., Okamura H., Fujishawa H., Itoi M., Yanaihara C., Yanaihara N., Ibata Y. VIP (Vasoactive Intestinal Peptide)-like immunoreactive amacrine cells in the retina of the rat. Exp. Eye Res. 36: 743, 1983.

    PubMed  CAS  Google Scholar 

  38. Barajas L., Sokolski D.N., Lechago J. Vasoactive intestinal polypeptide-immunoreactive nerves in the kidney. Neurosci. Lett. 43: 263, 1983.

    PubMed  CAS  Google Scholar 

  39. O’Dorisio M.S., O’Dorisio T.M., Cataland S., Balcerzak S.P. Vasoactive intestinal polypeptide as a biochemical marker for polymorphonuclear leukocytes. J. Lab. Clin. Med. 96: 666, 1980.

    PubMed  Google Scholar 

  40. Cutz E., Chan W., Track N.S., Goth A., Said S.I. Release of vasoactive intestinal polypeptide in mast cells by histamine liberators. Nature 275: 661, 1978.

    PubMed  CAS  Google Scholar 

  41. Giachetti A., Goth A., Said S.I. Vasoactive intestinal polypeptide (VIP) in rabbit platelets and rat mast cells. Fed. Proc. 37: 657, 1978.

    Google Scholar 

  42. Eiden E., Eskay R.L., Scott J., Pollard H., Hotchkiss A.J. Primary cultures of bovine chromaffin cells synthesize and secrete VIP. Life Sci. 33: 687, 1983.

    PubMed  CAS  Google Scholar 

  43. Makhlouf G.M., Said S.I. The effect of vasoactive intestinal peptide (VIP) on digestive and hormonal function. In: Thompson J.C. (Ed.), Gastrointestinal hormones. University of Texas Press, Austin, 1975, p. 599.

    Google Scholar 

  44. Schwartz C.J., Kimberg D.V., Sheerin H.E., Field M., Said S.I. Vasoactive intestinal peptide stimulation of adenylate cyclase and active electrolyte secretion in intestinal mucosa. J. Clin. Invest. 54: 536, 1974.

    PubMed Central  PubMed  CAS  Google Scholar 

  45. Laburthe M., Besson J., Hui Bon Hoa D., Rosselin G. Récepteurs du, peptide intestinal vasoactif (VIP) dans les entérocytes: Liaison spécifique et stimulation de I’AMP cyclique. C.R. Acad. Sci. (Paris) 284: 2139, 1977.

    CAS  Google Scholar 

  46. Frandsen E.K., Moody A.J. Lipolytic action of a newly isolated vasoactive intestinal polypeptide. Horm. Metab. Res. 5: 196, 1973.

    PubMed  CAS  Google Scholar 

  47. Desbuquois B., Laudat M.H., Laudat P. Vasoactive intestinal polypeptide and glucagon: Stimulation of adenylate cyclase activity via distinct receptors in liver and fat cell membranes. Biochem. Biophys. Res. Commun. 53: 1187, 1973.

    Google Scholar 

  48. Kowal J., Horst I., Pensky J., Alfonzo M. A comparison of the effects of ACTH, vasoactive intestinal peptide, and cholera toxin on adrenal cAMP and steroid synthesis. Ann. N.Y. Acad. Sci. 297: 314, 1977.

    PubMed  CAS  Google Scholar 

  49. Rattan S., Said S.I., Goyal R.K. Effect of vasoactive intestinal polypeptide (VIP) on the lower esophageal sphincter pressure (LESP). Proc. Soc. Exp. Biol. Med. 155: 40, 1977.

    PubMed  CAS  Google Scholar 

  50. Ryan J., Cohen G. Effect of vasoactive intestinal polypeptide (VIP) on basal and cholecystokinin-induced gallbladder-pressure. Gastroenterology 73: 870, 1977.

    PubMed  CAS  Google Scholar 

  51. Phillis J.W., Kirkpatrick J.R., Said S.I. Vasoactive intestinal polypeptide excitation of central neurons. Can. J. Physiol. Pharmacol. 56: 337, 1977.

    Google Scholar 

  52. Quik M., Iversen L., Bloom S.R. Effect of vasoactive intestinal peptide (VIP) and other peptides on cAMP accumulation in rat brain. Biochem. Pharmacol. 27: 2209, 1978.

    PubMed  CAS  Google Scholar 

  53. Borghi C., Nicosia S., Giachetti A., Said S.I. Vasoactive intestinal polypeptide (VIP) stimulates adenylate cyclase in selected areas of rat brain. Life Sci. 24: 65, 1978.

    Google Scholar 

  54. Said S.I. Vasodilator action of VIP: Introduction and general considerations. In: Said S.I. (Ed.), Vasoactive intestinal peptide. Raven Press, New York, 1982, p. 145.

    Google Scholar 

  55. McCulloch J., Kelly P.A.T., Uddman R., Edvinsson L. Functional role for vasoactive intestinal polypeptide in the caudate nucleus: a 2-deoxy[14C]-glucose investigation. Proc. Natl. Acad. Sci. USA 80: 1472, 1983.

    PubMed Central  PubMed  CAS  Google Scholar 

  56. Riou F., Cespuglio R., Jouvet M. Proprietés hypnogenes du vasoactive intestinal polypeptide chez le rat. C.R. Acad. Sci. (Paris) 293: 679, 1981.

    CAS  Google Scholar 

  57. Hohmann E.L., Levine L., Tashjian A.H. Vasoactive intestinal peptide stimulates bone resorption via a cyclic adenosine 3’,5’-monophosphate dependent mechanism. Endocrinology 112: 1233, 1983.

    PubMed  CAS  Google Scholar 

  58. Smitherman T.C., Sakio H., Geumei A.M., Yoshida T., Oyamada M., Said S.I. Coronary vasodilator action of VIP. In: Said S.I. (Ed.), Vasoactive intestinal peptide. Raven Press, New York, 1982, p. 169.

    Google Scholar 

  59. Ottesen B., Staun-Olsen P., Gammeltoft S., Fahrenkrug J. Receptors for vasoactive intestinal polypeptide on crude smooth muscle membranes from porcine uterus. Endocrinology 110: 2037

  60. Laburthe M., Amiranoff B., Rosselin G. Peptidergic regulation of the cyclic AMP system in the intestinal epithelium. Adv. Physiol. Sci. 12: 175, 1981.

    CAS  Google Scholar 

  61. Robberecht P., Chatelain P., De Neef P., Camus J.-C., Waelbroeck M., Christophe J. Presence of vasoactive intestinal peptide receptors coupled to adetiylate cyclase in rat lung membranes. Biochim. Biophys. Acta 678: 76, 1981.

    PubMed  CAS  Google Scholar 

  62. Kaneko T., Ctieng P.-Y., Oka H., Oda T., Yanaihara N., Yanaihara C. Vasoactive intestinal polypeptide stimulates adenylate cyclase and serotonin N-acetyltransferase activities in rat pineal in vitro. Biochem. Res. 1: 84, 1980.

    Google Scholar 

  63. Chatelain P., Robberecht P., Waelbroeck M., De Neef P., Camus J.-C., Huu A.N., Roba J., Christophe J. Topographical distribution of the secretin- and VIP-stimulated adenylate cyclase system in the hearth of five animal species. Pfluegers Arch. 397: 100, 1983.

    CAS  Google Scholar 

  64. Beed E.A., O’Dorisio M.S., O’Dorisio T.M., Gaginella T.S. Demonstration of a functional receptor for vasoactive intestinal polypeptide on Molt 4b T lymphoblasts. Regul. Pept. 6: 1, 1983.

    PubMed  CAS  Google Scholar 

  65. Bitar K.N., Makhlouf G.M. Relaxation of isolated gastric smooth muscle cells by vasoactive intestinal peptide. Science 216: 531, 1982.

    PubMed  CAS  Google Scholar 

  66. Dharmsathaphorn K., Harms V., Yamashiro D.J., Hughes R.J., Binder H.J., Wright E.M. Preferential binding of vasoactive intestinal polypeptide to basolateral membrane of rat and rabbit enterocytes. J. Clin. Invest. 71: 27, 1983.

    PubMed Central  PubMed  CAS  Google Scholar 

  67. Amiranoff B., Rosselin G. VIP receptors and control of cyclic AMP production. In: Said S.I. (Ed.), Vasoactive intestinal peptide. Raven Press, New York, 1982, p. 307.

    Google Scholar 

  68. Laburthe M., Bataille D., Rousset M., Besson J., Broer Y., Zweibaum A., Rosselin G. In: Nicholls P., Muller J.V., Jorgensen P.L., Moody A.J. (Eds.), Membrane protein. Pergamon Press, New York, 1978, p. 271.

  69. Robberecht P., Waelbroeck M., Camus J.-C., De Neef P., Christophe J. Importance of disulfide bonds in receptors for vasoactive intestinal peptide and secretin in rat pancreatic plasma membranes. Biochem. Biophys. Acta 773: 271, 1984.

    PubMed  CAS  Google Scholar 

  70. Sarrieau A., Laburthe M., Rosselin G. Intestinal VIP receptors: differential effect of trypsin on the high and low affinity binding sites. Mol. Cell. Endocrinol. 31: 301, 1973.

    Google Scholar 

  71. Sarrieau A., Boige N., Laburthe M. Role of phospholipids in the binding activity of vasoactive intestinal peptide receptors. Experientia 41: 631, 1985.

    PubMed  CAS  Google Scholar 

  72. Paul S., Said S.I. Solubilization of active receptors for VIP from guinea pig lung. Peptides 1986, in press.

  73. Laburthe M., Breant B., Rouyer-Fessard C. Molecular identification of receptors for vasoactive intestinal peptide in rat intestinal peptide in rat intestinal epithelium by covalent cross-linking. Evidence for two classes of binding sites with different structural and functional properties. Eur. J. Biochem. 139: 181, 1984.

    PubMed  CAS  Google Scholar 

  74. Muller J.-M., Luis J., Fantini J., Abadie B., Giannellini F., Marvaldi J., Pichon J. Covalent cross-linking of vasoactive intestinal peptide (VIP) to its receptor in intact colonic adenocarcinoma cells in culture (HT 29). Eur. J. Biochem. 151: 411, 1985.

    PubMed  CAS  Google Scholar 

  75. Wood C.L., O’Dorisio M.S. Covalent cross-linking of vasoactive intestinal polypeptide to its receptors on intact human lymphoblasts. J. Biol. Chem. 260: 1243, 1985.

    PubMed  CAS  Google Scholar 

  76. Fahrenkrug J., Galbo H., Holtz J.J., Schaffalitzky de Muckadell O.B. Influence of the autonomic nervous system on the release of vasoactive intestinal polypeptide from the porcine gastrointestinal tract. J. Physiol. 280: 405, 1978.

    PubMed Central  PubMed  CAS  Google Scholar 

  77. Fahrenkrug J., Otesen B. Nervous release of vasoactive intestinal polypeptide from the feline uterus: pharmacological characteristics. J. Physiol. 331: 451, 1982.

    PubMed Central  PubMed  CAS  Google Scholar 

  78. Anderson P.-O., Bloom S.R., Edwards V., Järhult J. Effects of stimulation of the chorda tympani in bursts on submaxillary responses in the cat. J. Physiol. 322: 469, 1982.

    Google Scholar 

  79. Bitar K.N., Said S.I., Weir G.C., Saffouri B., Makhlouf G.M. Neural release of vasoactive intestinal peptide from the gut. Gastroenterology 79: 1288, 1980.

    PubMed  CAS  Google Scholar 

  80. Gaginella T.S., O’Dorisio T.M., Hubel K.A. Release of vasoactive intestinal polypeptide by electrical field stimulation of rabbit ileum. Regul. Pept. 2: 165, 1981.

    PubMed  CAS  Google Scholar 

  81. Straus E., Keltz T.N., Yalow R.S. Enzymatic degradation of VIP. In: Said S.I. (Ed.), Vasoactive intestinal peptide. Raven Press, New York, 1982, p. 333.

    Google Scholar 

  82. Kitamura S., Ishihara Y., Said S.I. Effect of VIP, phenoxybenzamine and prednisolone on cyclic nucleotide content of isolated guinea-pig lung and trachea. Eur. J. Pharmacol. 67: 219, 1980.

    PubMed  CAS  Google Scholar 

  83. Domschke S., Domschke W., Bloom S.R., Mitznegg P., Mitchell S., Lux G., Strunz U., Demling L. Pharmacokinetics and pharmacodynamics In: Bloom S.R. (Ed.), Gut hormones. Churchill Livingstone, New York, 1978, p. 475.

    Google Scholar 

  84. Lundberg J.M. Evidence for coexistence of vasoactive intestinal polypeptide (VIP) and acetylcholine in neurons of cat exocrine glands. Acta Physiol. Scand. (Suppl.) 496: 1, 1981.

    CAS  Google Scholar 

  85. Eckenstein F., Baughman R.W. Two types of cholinergic innervation in cortex, one colocalized with vasoactive intestinal polypeptide. Nature 309: 153, 1984.

    PubMed  CAS  Google Scholar 

  86. Hara H., Hamill G.S., Jacobowitz D.M. Origin of cholinergic nerves to the rat major cerebral arteries: Coexistence with vasoactive intestinal polypeptide. Brain Res. Bull. 14: 179, 1985.

    PubMed  CAS  Google Scholar 

  87. Pruss R.M., Moskal J.R., Eiden L.E., Beinfeld M.C. Specific regulation of vasoactive intestinal polypeptide biosynthesis by phorbol ester in bovine chromaffin cells. Endocrinology 117: 1020, 1985.

    PubMed  CAS  Google Scholar 

  88. Lundberg J.M., Fahrendrug J., Larsson O., Änggård A. Corelease of vasoactive intestinal polypeptide and peptide histidine isoleucine in relation to atropine-resistant vasodilation in cat submandibular salivary gland. Neurosci. Lett. 52: 37, 1984.

    PubMed  CAS  Google Scholar 

  89. Lebolenger F., Leroux P., Delarue C., Tonon M.C., Charnay Y., Dubois P.M., Coy D.H., Vaudry H. Co-localization of vasoactive intestinal peptide (VIP) and enkephalins in chromaffin cells of the adrenal gland of amphibia. Stimulation of corticosteroid production by VIP. Life Sci. 32: 375, 1983.

    Google Scholar 

  90. Ekblad E., Håkanson R., Sundler F. VIP and PHI coexist with and NPY-like peptide in intramural neurones of the small intestine. Regul. Pept. 10: 47, 1984.

    PubMed  CAS  Google Scholar 

  91. Bataille D., Talbot J.-N., Milhaud G., Mutt V., Rosselin G. Effet du peptide intestinal vasoactif (VIP) sur la secretion de prolactin chez l’homme. C.R. Acad. Sci. (Paris) 292: 511, 1981.

    CAS  Google Scholar 

  92. Frawley L.S., Neill J.D. Stimulation of prolactin secretion in rhesus monkeys by vasoactive intestinal polypeptide. Neuroendocrinology 33: 79, 1981.

    PubMed  Google Scholar 

  93. Chihara K., Iwasaki J., Minamitani N., Kaji H., Matsukura S., Tamaki N., Matsumota S., Fujita T. Effect of vasoactive intestinal polypeptide on growth hormone secretion in perfused acromegalic pituitary adenoma tissues. J. Clin. Endocrinol. Metab. 54: 733, 1982.

    Google Scholar 

  94. Oliva D., Nicosia S., Spada A., Giannattasio G.L VIP stimulates ACTH release and adenylate cyclase in human ACTH-secreting pituitary adenomas. Eur. J. Pharmacol. 83: 101, 1982.

    PubMed  CAS  Google Scholar 

  95. Westendorf J.M., Phillips M.A., Schonbrunn A. Vasoactive intestinal peptide stimulates hormone retease from corticotropic cells in culture. Endocrinology 112: 550, 1983.

    PubMed  CAS  Google Scholar 

  96. Samson W.K., Burton K.P., Reeves J.P., McCann S.M. Vasoactive intestinal peptide stimulates luteinizing hormone-releasing hormone release from median eminence synaptosomes. Regul. Pept. 2: 253, 1981.

    PubMed  CAS  Google Scholar 

  97. Saffouri B., DuVal J.W., Arimura A., Makhlouf G.M. Effects of vasoactive intestinal peptide and secretin on gastrin and somatostatin secretion in the perfused rat stomach. Gastroenterology 86: 839, 1984.

    PubMed  CAS  Google Scholar 

  98. Porter J.P., Saicj S.I., Ganong W.F. Vasoactive intestinal peptide stimulates renin secretion in vitro: evidence for a direct action of the peptide on the renal juxtaglomerular cells. Neuroendocrinology 36: 404, 1983.

    PubMed  CAS  Google Scholar 

  99. Ganong W.F., Porter J.P., Bahnson T.D., Said S.I. Peptides and neurotransmitters that affect renin secretion. J. Hypertension 2(Suppl. 1): 75, 1984.

    CAS  Google Scholar 

  100. Porter J.P., Thrasher T.N., Said S.I., Ganong W.F. Vasoactive intestinal peptide in the regulation of renin secretion. Am. J. Physiol. 249: F84, 1985.

    PubMed  CAS  Google Scholar 

  101. Villar H.V., Fender H.R., Rayford P.L., Ramus N.I., Thompson J.C. Inhibition of gastrin release and gastric secretion by GIP and VIP. In: Thompson J.C. (Ed.), Gastrointestinal hormones. University of Texas Press, Austin, 1975, p. 467.

    Google Scholar 

  102. Epelbaum J., Tapia-Arancibia L., Besson J., Rotsztejn W.H., Kordon C. Vasoactive intestinal peptide inhibits release of somatostatin from hypothalamus in vitro. Eur. J. Pharmacol. 58: 493, 1979.

    PubMed  CAS  Google Scholar 

  103. Undem B.J., Dick E.C., Buckner C.K. Inhibition by vasoactive intestinal peptide of antigen-induced histamine release from guinea-pig minced lung. Eur. J. Pharmacol. 88: 247, 1983.

    PubMed  CAS  Google Scholar 

  104. Gespach C., Hui Bon Hoa D., Rosselin G. Regulation by vasoactive intestinal peptide, histamine, somatostatin-14 and -28 of cyclic adenosine monophospate levels in gastric glands isolated from the guinea pig fundus or antrum. Endocrinology 112: 1597, 1983.

    PubMed  CAS  Google Scholar 

  105. Said S.I. VIP overview. In: Bloom S.R. and Polak J.M. (Eds.), Gut hormones, ed. 2. Churchill Livingstone, Edinburgh, 1981, p. 379.

    Google Scholar 

  106. Hedlung B., Abens J., Bartfai T. Vasoactive intestinal polypeptide and muscarinic receptors: Supersensitivity induced by long-term atropine treatment. Science 220: 519, 1983.

    Google Scholar 

  107. Shimatsu A., Kato Y., Matsushita N., Katakami H., Yanaihara N., Imura H. Stimulation by serotonin of vasoactive intestinal polypeptide release into rat hypophysial portal blood. Endocrinology 111: 338, 1982.

    PubMed  CAS  Google Scholar 

  108. Uvnäs-Moberg K., Goiny M., Posloncec B., Blomquist L. Increased levels of VIP (vasoactive intestinal polypeptide)-like immunoreactivity in peripheral venous blood in dogs following injections of apomorphine and bromocriptine. Do dopaminergic agents induce gastric relaxation and hypotension by a release of endogenous VIP? Acta Physiol. Scand. 115: 373, 1982.

    PubMed  Google Scholar 

  109. Shimatsu A., Kato Y., Matsushita N., Katakami H., Ohta H., Yanaihara N., Imura H. Effects of prostaglandin E1 on vasoactive intestinal polypeptide release from the hypothalamus and on prolactin secretion from the pituitary in rats. Endocrinology 113: 2059, 1983.

    PubMed  CAS  Google Scholar 

  110. Otten U., Lorez H.P. Nerve growth factor increases substance P, cholecystokinin and vasoactive intestinal polypeptide immunoreactivities in primary sensory neurones of newborn rats. Neurosci. Lett. 34: 153, 1983.

    Google Scholar 

  111. Rostene W.H., Fishchette C.T., McEwen B.S. Modulation by vasoactive intestinal peptide (VIP) of serotonin receptors in the male rat brain. Abstracts of Neuroscience Meetings, 1982.

  112. Lundberg J.M., Änggård A., Fahrenkrug J., Hökfelt T., Mutt V. Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: Functional significance of coexisting transmitters for vasodilation and secretion. Proc. Natl. Acad. Sci. USA 77: 1651, 1980.

    PubMed Central  PubMed  CAS  Google Scholar 

  113. Kawatani M., Rutigliano M., De Groat W.C. Depolarization and muscarinic excitation induced in a sympathetic ganglion by vasoactive intestinal polypeptide. Science 229: 879, 1985.

    PubMed  CAS  Google Scholar 

  114. Magistretti P.J., Schorderet M. VIP and noradrenaline act synergistically to increase cyclic-AMP in cerebral cortex. Nature 308: 208, 1984.

    Google Scholar 

  115. Magistretti P.J., Schorderet M. Norepinephrine and histamine potentiate the increases in cyclic adenosine 3’: 5’-monophosphate elicited by vasoactive intestinal polypeptide in mouse cerebral cortical slices: mediation by a1 -adrenergic and H1 -histaminergic receptors. J. Neurosci. Res. 5: 362, 1985.

    CAS  Google Scholar 

  116. Onali P., Eva C., Olianas M.C., Schwartz J.P., Costa E. In GH3 pituitary cells asetylcholine and vasoactive intestinal peptide antagonistically modulate adenylate cyclase, cyclic AMP content, and prolactin secretion. Mol. Pharmacol. 24: 189, 1983.

    PubMed  CAS  Google Scholar 

  117. Onali P., Schwartz J.P., Costa E. Inhibition of VIP-sensitive adenylate cyclase by dopamine in rat anterior pituitary. In: Segawa T. (Ed.), Molecular pharmacology of neurotransmitter receptors. Raven Press, New York, 1983, p. 199.

    Google Scholar 

  118. Rotsztejn W.H., Benoist L., Besson J., Beraud G., Bluet-Pajot M.T., Kordon C., Rosselin G., Duval J. Effect of vasoactive intestinal peptide (VIP) on the release of adenohypophyseal hormones from purified cells obtained by unit gravity sedimentation. Inhibition by dexamethasone of VIP-induced prolactin release. Neuroendocrinology 31: 282, 1980.

    PubMed  CAS  Google Scholar 

  119. Carter R.F., Bitar K.N., Zfass A.M., Makhlouf G.M. Inhibition of VIP-stimulated intestinal secretion and cyclic AMP production by somatostatin in the rat. Gastroenterology 74: 726, 1978.

    PubMed  CAS  Google Scholar 

  120. Feliu J.E., Mojena M., Silverstre R.A., Monge J., Marco J. Stimulatory effect of vasoactive intestinal peptide on glycogenolysis and gluconeogenesis in isolated rat hepatocytes: antagonism by insulin. Endocrinology 112: 2120, 1983.

    PubMed  CAS  Google Scholar 

  121. Bloom S.R., Edwards A.V. Vasoactive intestinal peptide in relation to atropine resistant vasodilation in the submaxillary gland of the cat. J. Physiol. 300: 41, 1980.

    PubMed Central  PubMed  CAS  Google Scholar 

  122. Suzuki Y., McMaster D., Huang M., Lederis K., Rorstad O.P. Characterization of functional receptors for vasoactive intestinal peptide in bovine cerebral arteries. J. Neurochem. 45: 890, 1985.

    PubMed  CAS  Google Scholar 

  123. Lundberg J.M., Änggård A., Pernow J., Hökfelt T. Neuropeptide Y-, substance, P- and VlP-immunoreactive nerves in cat spleen in relation to autonomic vascular and volume control. Cell Tissue Res. 239: 9, 1985.

    PubMed  CAS  Google Scholar 

  124. Said S.I. Peptides, endothelium and pulmonary vascular reactivity. Chest 88: 207S, 1985.

    PubMed  CAS  Google Scholar 

  125. Goyal R.K., Rattan S., Said S.I. VIP as a possible neuro-transmitter of non-cholinergic non-adrenergic inhibitory neurones. Nature 288: 278, 1980.

    Google Scholar 

  126. Grider J.R., Cable M.B., Said S.I., Makhlouf G.M. Vasoactive intestinal peptide (VIP) as neural mediator of gastric relaxation. Am. J. Physiol. 248: G73, 1985.

    PubMed  CAS  Google Scholar 

  127. Grider J.R., Cable M.B., Bitar K.N., Said S.I., Makhlouf G.M. Vasoactive intestinal peptide: Relaxant neurotransmitter in tenia coli of the guinea pig. Gastroenterology 89: 36, 1985.

    PubMed  CAS  Google Scholar 

  128. Matsuzaki Y., Hamasaki Y., Said S.I. Vasoactive intestinal peptide: A possible transmitter of non-adrenergic relaxation of guinea pig airways. Science 210: 1252, 1980.

    PubMed  CAS  Google Scholar 

  129. Angel F., Go V.L.W., Schmalz P.F., Szurszewski J.H. Vasoactive intestinal polypeptide: A putative transmitter in the canine gastric muscularis mucosa. J. Physiol. 341: 641, 1983.

    PubMed Central  PubMed  CAS  Google Scholar 

  130. Gibson A., Tucker J.F. The effects of vasoactive intestinal polypeptide and of adenosine 5’-triphosphate on the isolated anococcygeus muscle of the mouse. Br. J. Pharmacol. 77: 97, 1982.

    PubMed Central  PubMed  CAS  Google Scholar 

  131. Lundberg J.M., Änggård A., Fahrenkrug J. Complementary role of vasoactive intestinal polypeptide (VIP) and acetylcholine for cat submandibular gland blood flow and secretion. II. Effects of cholinergic antagonists and VIP antiserum. Acta Physiol. Scand. 113: 329, 1981.

    PubMed  CAS  Google Scholar 

  132. Nathanson I., Widdicombe J.H., Barnes P.J. Effect of vasoactive intestinal peptide on ion transport across dog tracheal epithelium. J. Appl. Physiol. 55: 1844, 1983.

    PubMed  CAS  Google Scholar 

  133. Dartt D.A., Baker A.K., Vaillant C., Rose P.E. Vasoactive intestinal polypeptide stimulation of protein secretion from rat lacrimal gland acini. Am. J. Physiol. 247: G502, 1984.

    PubMed  CAS  Google Scholar 

  134. Abe H., Engler D., Molitch M.E., Bollinger-Gruber J., Reichlin S. Vasoactive intestinal peptide is a physiological mediator of prolactin release in the rat. Endocrinology 116: 1383, 1985.

    PubMed  CAS  Google Scholar 

  135. Fahrenkrug J., Emson P.C. Vasoactive intestinal polypeptide: Functional aspects. Br. Med. Bull. 38: 265, 1982.

    PubMed  CAS  Google Scholar 

  136. Willis E., Ottesen B., Wagner G., Sundler F., Fahrenkrug J. Vasoactive intestinal polypeptide (VIP) as a possible neurotransmitter involved in penile erection. Acta Physiol. Scand. 113: 545, 1981.

    PubMed  CAS  Google Scholar 

  137. Willis E.A., Ottesen B., Wagner G., Sundler F., Fahrenkrug J. Vasoactive intestinal polypeptide (VIP) as a putative neurotransmitter in penile erection. Life Sci. 33: 383, 1983.

    PubMed  CAS  Google Scholar 

  138. Rola-Pleszczynski M., Bolduc D., St.-Pierre S. The effects of vasoactive intestinal peptide on human natural killer cell function. J. Immunol. 135: 2569, 1985.

    PubMed  CAS  Google Scholar 

  139. O’Dorisio M.S., Wood C.L., O’Dorisio T.M. Vasoactive intestinal peptide and neuropeptide modulation of the immune response. J. Immunol. 135: 792s, 1985.

    PubMed  Google Scholar 

  140. Kane M.G., O’Dorisio T.M., Krejs G.J. Production of secretory diarrhea by intravenous infusion of vasoactive intestinal polypeptide. N. Engl. J. Med. 309: 1482, 1983.

    PubMed  CAS  Google Scholar 

  141. Hunt S., Vaamonde C.A., Rattassi T., Berian M.G., Said S.I., Papper S. Circulating levels of vasoactive intestinal polypeptide (VIP) in liver disease. Arch. Intern. Med, 139: 994, 1979.

    PubMed  CAS  Google Scholar 

  142. Modlin I.M., Bloom S.R., Mitchell S.J. Plasma vasoactive intestinal polypeptide (VIP) levels and intestinal ischemia. Experientia 34: 535, 1978.

    PubMed  CAS  Google Scholar 

  143. Revhaug A., Lygren I., Lundgren T.I., Andersen O.K., Burhol P.G., Giercksky K.E. Increased plasma levels of vasoactive intestinal polypeptide in pigs during endotoxinaemia. Eur. Surg. Res. 17: 75, 1985.

    PubMed  CAS  Google Scholar 

  144. Tsuto T., Okamura H., Fukui K., Obata H.L., Terubayashi H., Iwai N., Majima S., Yanaihara N., Ibata Y. An immunohistochemical investigation of vasoactive intestinal polypeptide in the colon of patients with Hirschsprung’s disease. Neurosci. Lett. 34: 57, 1982.

    PubMed  CAS  Google Scholar 

  145. Gridelli B., Buffa R., Salvini P., De Rai P., Uggeri F., Fiocca R., Said S.I. Lack of VIP-immunoreactive nerves in oesophageal achalasia. Ital. J. Gastroenterol. 14: 211, 1982.

    Google Scholar 

  146. Heinz-Erian P., Dey R.D., Said S.I. Deficient vasoactive intestinal peptide innervation in sweat glands of cystic fibrosis patients. Science 229: 1407, 1985.

    PubMed  CAS  Google Scholar 

  147. Gjerris A., Rafaelsen O.J., Vendsborg P., Fahrenkrug J., Rehfeld J.F. Vasoactive intestinal polypeptide decreased in cerebrospinal fluid (CSF) in atypical depression. Vasoactive intestinal polypeptide, cholecystokinin and gastrin in CSF in psychiatric disorders. J. Affect. Disorders 7: 325, 1984.

    PubMed  CAS  Google Scholar 

  148. Wikkelsø C., Fahrenkrug J., Blomstrand C., Johansson B.B. Dementia of different etiologies: Vasoactive intestinal polypeptide in CSF. Neurology 35: 592, 1985.

    PubMed  Google Scholar 

  149. Said S.I., Geumei A., Hara N. Bronchodilator effect of VIP in vivo: Protection against bronchoconstriction induced by histamine or prostaglandin F2α . In: Said S.I. (Ed.), Vasoactive intestinal peptide. Raven Press, New York, 1982, p. 185.

    Google Scholar 

  150. Wasserman M.A., Griffin R.L., Malo P.E. Comparative in vitro tracheal-relaxant effects of porcine and hen VIP. In: Said S.I. (Ed.), Vasoactive intestinal peptide. Raven Press, New York, 1982, p. 185.

    Google Scholar 

  151. Hamasaki Y., Saga T., Mojarad M., Said S.I. VIP couteracts leukotriene D4-induced contractions of guinea pig trachea, lung and pulmonary artery. Trans. Assoc. Am. Physicians 96: 406, 1983.

    PubMed  CAS  Google Scholar 

  152. Diamond L., Szarek J.L., Gillespie M.N., Altiere R.J. In vivo bronchodilator activity of vasoactive intestinal peptide in the cat. Am. J. Respir. Dis. 128: 827, 1983.

    CAS  Google Scholar 

  153. Mojarad M., Grode T.L., Cox C.P., Kimmel G., Said S.I. Differential responses of human asthmatics to inhaled vasoactive intestinal peptide (VIP). Am. Rev. Respir. Dis. 131: 281 A, 1985.

    Google Scholar 

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Said, S.I. Vasoactive intestinal peptide. J Endocrinol Invest 9, 191–200 (1986). https://doi.org/10.1007/BF03348097

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