Abstract
The aetiology of cardiac dysfunction caused by sarcoid granulomatous inflammation may be difficult to clarify, and the potential of imaging methods is limited. We report on a patient who presented with acute biventricular decompensation. Pulmonary sarcoidosis was confirmed after hospitalization. Four weeks after the initiation of corticosteroid treatment, scintigraphy with indium-111-labelled antimyosin antibody Fab fragments (AMAB) revealed distinct activity accumulation in major parts of the left ventricular wall (heart-lung ratio: 1.6) 72 h following injection. There may be a role for AMAB scintigraphy in the early detection of cardiac sarcoidosis.
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Bernstein M, Konzelmann FW, Sidlick DM (1929) Boeck's Sarcoid: report of case with visceral involvement. Arch Intern Med 44:721–734
Beyer J (1990) Glukokortikoidtherapie. In: Weihrauch TR (ed) Internistische Therapie, 8th edn Urban & Schwarzenberg, Munich, pp 106–120
Bulkey BH, Rouleau JR, Whitaker JQ, Strauss HW, Pitt B (1977) The use of 201-thallium for myocardial perfusion imaging in Sarcoid heart disease. Chest 72:27–32
Carrio I, Berna L, Ballester M et al. (1988) Indium-111-antimyosin scintigraphy to assess myocardial damage in patients with suspected myocarditis and cardiac rejection. J Nucl Med 29:1893–1900
Dec GW, Palacios I, Yasuda T, Fallon JT, Khaw BA, Strauss HW, Haber E (1990) Antimyosin antibody cardiac imaging: its role in the diagnosis of myocarditis. J Am Coll Cardiol 16:97–104
Fleming HA (1974) Sarcoid heart disease. Br Heart J 36:54–68
Flora GS, Sharma OP (1989) Myocardial sarcoidosis: a review. Sarcoidosis 6:97–106
Foreman MB, Sandler MP, Sacks GA et al. (1983) Radionuclide imaging in myocardial sarcoidosis: demonstration of myocardial uptake of technetium pyrophosphate 99m and gallium. Chest 83:578–580
Gentzen G (1937) Über Riesenzellengranulome bei zwei Fällen von Endocardfibrose, Beitr pathol Anat 51:376–398
Haywood IJ, Sharma OP, Siegel ME (1982) Detection of myocardial sarcoidosis by thallium-201 imaging. J Natl Med Assoc 74:959–965
Jain D, Zaret BL (1990) Antimyosin cardiac imaging in acute myocarditis. J Am Coll Cardiol 16:105–107
Khaw BA, Beller GA, Haber E, Smith TW (1976) Localization of cardiac myosin-specific antibody in myocardial infarction. J Clin Invest 58:439–446
Khaw BA, Fallon JT, Beller GA, Haber E (1979) Specificity of localization of myosin-specific antibody fragments in experimental myocardial infarction: histologic, histochemical, autoradiographic and scintigraphic studies. Circulation 60:1527–1531
Khaw BA, Gold HK, Yasuda T et al. (1986) Scintigraphic quantification of myocardial necrosis in patients after intravenous infection of myosin-specific antibody. Circulation 74:501–508
Kinney EL, Jackson GL, Reeves WC, Zelis R (1980) Thallium-scan myocardial defects and echocardiographic abnormalities in patients with sarcoidosis without clinical cardiac dysfunction. An analysis of 44 patients. Am J Med 68:497–503
Lemery R, McGodon MD, Edwards WD (1985) Cardiac sarcoidosis: a potentially treatable form of myocarditis. Mayo Clin Proc 60:549–554
Lorell B, Alderman EL, Mason JW (1978) Cardiac sarcoidosis; diagnosis with endomyocardial biopsy and treatment with corticosteroids. Am J Cardiol 42:143–146
Matsui Y, Iwai K, Tachibana T et al. (1976) Clinicopathological study of fatal myocardial sarcoidosis. Ann NY Acad Sci 278:455–469
Oakley C (1989) Cardiac sarcoidosis. Thorax 44:371–372
Porter GU (1960) Sarcoid heart disease. N Engl J Med 263:1350–1357
Roberts WC, McAllister HA, Ferrans VJ (1977) Sarcoidosis of the heart. A clinicopathologic study of 35 necropsy patients (group I) and review of 75 previously described necropsy patients (group II). Am J Med 63:86–108
Silverman KJ, Hutchins GM, Bulkley BH (1978) Cardiac Sarcoid: a clinicopathologic study of 84 unselected patients with systemic sarcoidosis. Circulation 58:1204–1211
Tajimu T, Naito T, Dohi Y, Miyamae T (1981) Ga-67 and Tl-201 imaging in sarcoidosis involving the myocardium. Clin Nucl Med 6:120–121
Valantine H, McKenna WJ, Nihoyannopoulos P et al. (1987) Sarcoidosis: a pattern of clinical and morphological presentation. Br Heart J 57:256–263
Yasuda T, Palacios IF, Dec GW et al. (1987) Indium-111 monoclonal antimyosin antibody imaging in the diagnosis of active myocarditis. Circulation 75:306–311
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Knapp, W.H., Bentrup, A. & Ohlmeier, H. Indium-111-labelled antimyosin antibody imaging in a patient with cardiac sarcoidosis. Eur J Nucl Med 20, 80–82 (1993). https://doi.org/10.1007/BF02261250
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DOI: https://doi.org/10.1007/BF02261250