Summary
We have studied 44 patients with Behçet's Disease (BD) to look for any correlation of arterial and venous thrombosis or central nervous system (CNS) manifestations with anti-cardiolipin antibodies (ACLA). Twenty patients were positive for ACLA by MELISA method. Ten patients had IgG antibody, four had IgM and six had both IgG and IgM. Of these patients, 11 had a history of vascular thrombosis and thrombophlebitis and nine had CNS manifestations. The association of ACLA with vascular thrombosis or CNS manifestation of Behçet's disease was statistically not significant.
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References
Harris, E.N., Gharavi, A.E., Boey, M.L., et al. Anticardiolipin antibodies: Detection by radioimmunoassay and association with thrombosis in SLE. Lancet 1983, ii, 1211–1214.
Soulier, P.R., Boffa, M.C. A vestment a repetition, thrombosis et anticoagulant circular antithromboplastine. Nouv Press Med 1980, 9, 859–64.
Lubbe, W.F., Walker, E.B. Chorea gravidarum associated with circulating lupus anticoagulant; successful outcome of pregnancy with prednisone and aspirin therapy. Br J Obstet Gynaecol 1983, 90, 487–90.
Harris, E.N., Chan, J.H.J., Asherson, R.A., Aber, V.R., Gharavi, A.E., Hughes, G.R.V. Thrombosis, recurrent fetal loss and thrombocytopenia. Arch Intern Med 1986, 146, 2153.
Asheron, R.A., Mackworth-Young, G.G., Boey, M.L., et al. Pulmonary hypertension in SLE. Br Med J 1983, 287, 1024.
Colaco, C.B., Scadding, G.K., Lockhart, S. Anticardiolipin antibodies in neurological disorders: Cross reaction with anti SSDNA activity. Clin Exp Immunol 1987, 68, 313.
Enylert, H., Boey, M.L., Derve, G., et al. Degos disease association with anticardiolipin antibodies and the lupus anticoagulant. Br Med J 1984.
Harris, E.N., Englert, H., Derve, G., Gharavi, A., Hughes, G.R.V. Antiphospholipid antibodies in acute Guillain Barre syndrome. Lancet 1983, i, 1361.
Mason, R.M., Barnes, C.G. Behçet's syndrome with arthritis. Ann Rheum Dis 1969, 28, 95–103.
Hull, R.G., Harris, E.N., Gharavi, A.E., et al. Anticardiolipin antibodies: occurrence in Behçet's syndrome. Ann Rheum Dis 1984, 43, 746–8.
Efthimiou, J., Harris, E.N., Hughes, G.R.V. Negative anticardiolipin antibodies and vascular complications in Behçet's syndrome (letter). Ann Rheum Dis 1985, 44, 725–6.
Chajek, T., Fainaru, M. Behçet's disease report of 41 cases and a review of the literature. Medicine 1975, 54, 179–96.
Shimizu, T., Ehrlich, G.E., Inasa, G., Hayashi, K. Behçet syndrome. Semin Arthritis Rheum 1979, 8, 223–260.
Hughes, R.A.C., Lehner, T. Neurological aspect of Behçet's syndrome. In: Behçet's Syndrome Clinical and Immunological Features. Proceedings of conference sponsored by the Royal Society of Medicine, February 1979, Eds: Lehner, T., Barnes, C.G., London Academic PRESS 1979, 241–58.
Harris, E.N., Gharavi, A., Boey, M.L. et al. Anticardiolipin antibodies detected by a new solid phase radioimmunoassay: Striking association with thrombosis. An Rheum Dis 1984, 43, 122 (abstract).
Morell, P. Myelin 2nd ed., Plenum Press, New York (1984).
Masuda, K., Inaba, G., Mizushima, Y., et al. A national survey of Behçet's disease in Japan. Jpn J Ophthalmol 1975, 19, 278.
Butti, G.B., Bruna, R. An ophthalmic report on Behçet's disease. In: International Symposium on Behçet's Disease. Eds: Monacelli, M., Nazzaro, P., Rome Basel, Karger 1966, 79–110.
Inaba, G., Aovama, J. Immunochemical studies on Neuro-Behçet's syndrome. Annual reports of the Behçet's Disease Research Committee of Japan 1974, 194.
Pallis, C.A., Fudge, B.J. The neurological complications of Behçet's syndrome. Arch Neurol Psychiat 1956, 75, 1–14.
Wolf, S.M., Schotland, D.L., Phillips, L.L. Involvement of nervous system in Behçet's syndrome. Arch Neurol 1965, 12, 15–25.
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Al-Dalaan, A.N., Al-Ballaa, S.R., Al-Janadi, M.A. et al. Association of anti-cardiolipin antibodies with vascular thrombosis and neurological manifestation of Behçets disease. Clin Rheumatol 12, 28–30 (1993). https://doi.org/10.1007/BF02231554
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DOI: https://doi.org/10.1007/BF02231554