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Progressive multifokale Leukoenzephalopathie bei Wegener'scher Granulomatose unter Therapie mit Cyclosporin A

Progressive multifocal leukoencephalopathy in a patient with Wegener's granulomatosis treated with cyclosporin a

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Summary

A female patient with Wegener's granulomatosis developed severe bone marrow depression after two years treatment with cyclophosphamide. Corticosteroids alone could not sufficiently suppress disease activity, therefore additive therapy with Cyclosporin A was started. Four weeks later the patient developed a central nervous system disorder with affective disturbances and progressive somnolence. However, inspite of intensive diagnostic procedures, no definite diagnosis could be established. After another two months she died. Post-mortem-examination showed progressive multifocal leukoencephalopathy. An association between immunosuppressive therapy and reactivation of JC-Virus is suggested.

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Abbreviations

PML:

Progressive multifokale Leukoenzephalopathie

WG:

Wegener'sche Granulomatose

CyA:

Cyclosporin A

(C)CT:

(Craniale)Computertomographie

NMR:

Nuclear Magnetic Resonance (Kernspintomographic)

ZNS:

Zentralnervensystem

AIDS:

Acquired Immuno-deficiency Syndrome

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Ettinger, J., Feiden, W., Hübner, G. et al. Progressive multifokale Leukoenzephalopathie bei Wegener'scher Granulomatose unter Therapie mit Cyclosporin A. Klin Wochenschr 67, 260–264 (1989). https://doi.org/10.1007/BF01717330

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  • DOI: https://doi.org/10.1007/BF01717330

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