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Interleukin-10 (IL-10) secretion in systemic lupus erythematosus and rheumatoid arthritis: IL-10-dependent CD4+CD45RO+ T cell-B cell antibody synthesis

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Abstract

Interleukin-10 (IL-10) is a major immunoregulatory cytokine and has a multitude of immunomodulatory effects in the immune system. In this study, we have examined the secretion andin vitro function of IL-10 in B cell hyperactivity in antibody production in two common autoimmune diseases, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). IL-10 was detectable in serum of all active SLE and serum and synovial fluid samples of all RA patients but in none of the normal controls. B cells and CD4+CD45RO+ “memory” T cells secreted highly enhanced levels of IL-10 in SLE and RA versus normals. Increased IgM and IgG production by B cells-CD4+CD45RO+ T cells in SLE and RA was IL-10 dependent, since neutralization of IL-10 cytokine by anti-IL-10 antibody drastically reduced Ig synthesis in these coculture experiments. B cell hyperactivity in autoantibody production in SLE and RA may be a function of IL-10-dependent CD4+CD45RO+ Th2 cell activation. Therefore, IL-10 may play an important role in highly disturbed immune system and B cell-T cell function in these immune disorders.

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Authors and Affiliations

  1. Department of Internal Medicine (Rheumatology, King Saud University, College of Medicine, Abha, Saudi Arabia

    Mansour Al-Janadi, Suliman Al-Balla & Mohammed Al-Humaidi

  2. Tumor Immunology Unit (MBC 03), King Faisal Specialists Hospital & Research Center, P.O. Box 3354, 11211, Riyadh, Saudi Arabia

    Abdullah Al-Dalaan & Syed Raziuddin

Authors
  1. Mansour Al-Janadi
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  2. Abdullah Al-Dalaan
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  3. Suliman Al-Balla
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  4. Mohammed Al-Humaidi
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  5. Syed Raziuddin
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Al-Janadi, M., Al-Dalaan, A., Al-Balla, S. et al. Interleukin-10 (IL-10) secretion in systemic lupus erythematosus and rheumatoid arthritis: IL-10-dependent CD4+CD45RO+ T cell-B cell antibody synthesis. J Clin Immunol 16, 198–207 (1996). https://doi.org/10.1007/BF01541225

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