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Nonsteroidal anti-inflammatory drug-induced gastrointestinal toxicity: New insights into an old problem

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Abstract

Nonsteroidal anti-inflammatory drugs are widely used for the treatment of chronic arthropathies, but their gastrointestinal damage remains a significant limitation to their use. In this review, the pathogenic mechanisms through which these drugs are believed to cause gastrointestinal damage are outlined. A better understanding of the pathogenesis of gastric and intestinal injury has resulted in novel strategies that are being employed to develop nonsteroidal anti-inflammatory drugs that do not have significant adverse effects on the gastrointestinal tract.

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  1. Intestinal Disease Research Unit, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, T2N 4N1, Calgary, Alberta, Canada

    Neal M. Davies & John L. Wallace

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Davies, N.M., Wallace, J.L. Nonsteroidal anti-inflammatory drug-induced gastrointestinal toxicity: New insights into an old problem. J Gastroenterol 32, 127–133 (1997). https://doi.org/10.1007/BF01213310

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