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An 8-year follow-up study of pulmonary function in patients with rheumatoid arthritis

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Abstract

To evaluate longitudinal alterations in pulmonary function, 63 patients suffering from rheumatoid arthritis (RA) with previously reported reduced pulmonary diffusing capacity were re-examined in an 8-year follow-up study. Cross-sectional examination revealed normal values for vital capacity (VC), forced expiratory volume in 1 s (FEV1) and diffusing capacity per litre alveolar volume (KCO). Total diffusing capacity (DLCO; P>0.0001), maximal expiratory flow at 75% of expired VC (MEF 75; P>0.0001) and MEF 50 (P>0.01) were decreased. Longitudinal evaluation revealed unchanged MEF50, MEF75 and FEV1, whereas increases in DLCO (P>0.0001) and KCO (P>0.0001) and a decrease in VC (P>0.05) were found. The longitudinal changes in diffusing capacity were unrelated to patient age, disease duration, disease activity in the study period or pulmonary function at the first examination. Thus, in patients suffering from RA, the most prominent functional pulmonary abnormality, decreased diffusing capacity, appeared to improve in the course of time, despite a slight decrease in VC and continued articular disease activity.

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References

  1. Ellman P, Ball RE (1948) “Rheumatoid disease” with joint and pulmonary manifestations. BMJ 2:816

    Google Scholar 

  2. Raven RV, Wever FP, Price LW (1948) Necrobiotic nodules of rheumatoid arthritis. Ann Rheum Dis 7:63–75

    Google Scholar 

  3. Petty PL, Wilkins M (1966) The five manifestations of rheumatoid lung. Dis Chest 49:75–82

    Google Scholar 

  4. Popper MSD, Bogdonof ML, Hughes RL (1972) Interstitial rheumatic lung disease. Chest 62:243–250

    Google Scholar 

  5. Brannan HM, Good CA, Divertie MB et al (1964) Pulmonary disease associated with rheumatoid arthritis. JAMA 21:914–918

    Google Scholar 

  6. Martel W, Abell M, Mikkelsen WM et al (1968) Pulmonary and pleural lesions in rheumatoid disease. Radiology 90:641–653

    Google Scholar 

  7. Oxholm P, Madsen EB, Manthorpe R et al (1982) Pulmonary function in patients with rheumatoid arthritis. Scand J Rheumatol 11:109–112

    Google Scholar 

  8. Laitinen O, Salorinne Y, Poppius H (1973) Respiratory function in systemic lupus erythematosus, scleroderma, and rheumatoid arthritis. Ann Rheum Dis 32:531–535

    Google Scholar 

  9. Andonopoulos AP, Constantopoulos SH, Drosos AA et al (1988) Pulmonary function of nonsmoking patients with rheumatoid arthritis in the presence and absence of secondary Sjögren's syndrome, a controlled study. Respiration 53:251–258

    Google Scholar 

  10. Ropes MV, Bennett GA, Cobb S (et al (1958) 1958 revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis 9:175

    Google Scholar 

  11. Cotes JE (1979) Lung function. Assessment and application in medicine, 4th ed. Blackwell Scientific, Oxford

    Google Scholar 

  12. Mielke H, Daniel W, Deicher H, Sybrecht VH et al (1987) A three-year prospective study of systemic manifestation in rheumatoid arthritis. Clin Rheumatol 62:26–34

    Google Scholar 

  13. Cruickshank B (1954) The arteritis of rheumatoid arthritis. Ann Rheum Dis 13:136–146

    Google Scholar 

  14. Bywaters EGL (1957) Peripheral vascular obstruction in rheumatoid arthritis and its relationship to other vascular lesions. Ann Rheum Dis 16:84–103

    Google Scholar 

  15. Huang CT, Lyons HA (1966) Comparison of pulmonary function in patients with systemic lupus eryhtematosus, scleroderma and rheumatoid arthritis. Am Rev Respir Dis 93:865–875

    Google Scholar 

  16. Roschmann RA, Rothenburg RJ (1987) Pulmonary fibrosis in rheumatoid arthritis: a review of clinical features and therapy. Semin Arthritis Rheum 16:174–185

    Google Scholar 

  17. Frank DT, Weg JG, Harkelroad LE et al (1973) Pulmonary dysfunction in rheumatic disease. Chest 63:27–34

    Google Scholar 

  18. van der Schee AC, Dinkla BA, Festen JJM (1989) Penicillamine for interstitial lung disease in rheumatoid arthritis. Respiration 56:134–136

    Google Scholar 

  19. Weinrib L, Sharma OP, Quismorio O (1990) A long-term study of interstitial lung disease in systemic lupus erythematosus. Semin Arthritis Rheum 20:48–56

    Google Scholar 

  20. Linstow M, Kriegbaum NJ, Backer V et al (1990) A follow-upstudy of pulmonary function in patients with primary Sjögren's syndrome. Rheumatol 10:47–49

    Google Scholar 

  21. Schatz M, Patterson R, Fink J (1979) Immunologic lung disease. N Engl J Med 300:1310

    Google Scholar 

  22. Hazes JMW, Dijkmans BAC, Vandenbroucke JP et al (1990) Lifestyle and the risk of rheumatoid arthritis: cigarette smoking and alcohol consumption. Ann Rheum Dis 49:980–982

    Google Scholar 

  23. Mountz JD, Turner RA, Collins et al (1984) Rheumatoid arthritis and small airways function. Arthritis Rheum 27:728–736

    Google Scholar 

  24. Tuomi T, Helioevaara M, Palosuo T et al (1990) Smoking, lung function, and rheumatoid factors. Ann Rheum Dis 49:753–756

    Google Scholar 

  25. Schapira D, Nahir M, Scharf Y (1985) Pulmonary injury induced by gold salts treatment. Rev Roum Med Med Int 23:259–263

    Google Scholar 

  26. Chakravarty KK, Webley M (1990) The effect of gold and penicillamine in pulmonary function in rheumatoid arthritis — a longitudinal study. Br Soc Rheum 7th annual meeting 29:[Suppl no. 2]283

    Google Scholar 

  27. Carson CW, Cannon CW, Egger MJ et al (1987) Pulmonary disease during the treatment of rheumatoid arthritis with low dose pulse methotrexate. Semin Arthritis Rheum 16:186–195

    Google Scholar 

  28. Erhart CC, Mumford PA, Vables PJW et al (1989) Factors predicting a poor life prognosis in rheumatoid arthritis: an eight year prospective study. Ann Rheum Dis 48:7–13

    Google Scholar 

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Linstow, M., Ulrik, C.S., Kriegbaum, N.J. et al. An 8-year follow-up study of pulmonary function in patients with rheumatoid arthritis. Rheumatol Int 14, 115–118 (1994). https://doi.org/10.1007/BF00300812

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  • DOI: https://doi.org/10.1007/BF00300812

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