Regular ArticleSerum Anti-β2-glycoprotein I Antibodies from Patients with Antiphospholipid Antibody Syndrome Bind Central Nervous System Cells
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The immunologic etiology of psychiatric manifestations in systemic lupus erythematosus: A narrative review on the role of the blood brain barrier, antibodies, cytokines and chemokines
2020, Autoimmunity ReviewsCitation Excerpt :However, APL are also associated with direct neuronal damage by inducing oxidative stress and damage to neuronal cell membranes via β2-glycoprotein. This second mechanism seems to play a more important role in the pathophysiology of psychiatric NPSLE [164–167]. ANA are directed against nuclear antigens and, amongst others, consist of anti-double stranded DNA (anti-dsDNA), anti- Ro, anti-La, anti-Smith (anti-Sm) and anti-ribosomal protein (anti-RP).
Antiphospholipid antibodies in epilepsy: A systematic review and meta-analysis
2018, Autoimmunity ReviewsCitation Excerpt :In fact, key changes contributing to hyperexcitability in epileptic tissue can be directly linked to changes in astrocyte function [41]. Interestingly, aPLs (i.e., anti-β2-GPI) were reported to be immunoreactive and were able to bind directly with astrocytes [42] which indicate towards a possible aPLs-mediated activation of astrocytes followed by hyperexcitability in epileptic subjects. There is a lack of firm evidence of pathogenic direct links between the contribution of aCL and the development of epilepsy, however, it has been proposed that aCL antibodies might act against the neuronal phospholipids including phosphatidylcholine [26, 43].
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Correspondence to: Guido Valesini, Allergologia e Immunologia Clinica III, Policlinico Umberto I, 00161 Roma, Italy. Fax: 39-6-4940594. E-mail:[email protected]