Regular ArticleRole of PI 3-Kinase in Angiopoietin-1-Mediated Migration and Attachment-Dependent Survival of Endothelial Cells
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2019, Bioorganic and Medicinal ChemistryTargeting the Angiopoietin-2/Tie-2 axis in conjunction with VEGF signal interference
2016, Cancer LettersCitation Excerpt :The endothelium-specific vascular endothelial–phosphotyrosine phosphatase (VE-PTP) has also been shown to mediate cross talk between the Ang-1/Tie2 and VEGF/VEGFR pathways [26]. Ang-1 phosphorylation of Tie2 stimulates pro-survival pathways, such as PI3K-AKT and MAPK/ERK, as well as represses pro-inflammatory pathways through NF-κβ [27–29] indicating that Ang-1 can promote a stable, quiescent vasculature through various signaling modalities. Ang-2 is stored in Weibel–Palade bodies in endothelial cells and secreted upon microenvironmental changes [30–33].
The miR-126 regulates Angiopoietin-1 signaling and vessel maturation by targeting p85β
2012, Biochimica et Biophysica Acta - Molecular Cell ResearchAngiopoietin 1 reduces rat follicular atresia mediated by apoptosis through the PI3K/Akt pathway
2011, Molecular and Cellular EndocrinologyCitation Excerpt :Several studies have reported that ANGPT1 inhibits endothelial cell apoptosis through several pathways, including PI3K/AKT activation and upregulation of survivin protein (Harfouche et al., 2002; Papapetropoulos et al., 2000). Several researchers have focused on the role of this pathway in explaining the antiapoptotic effects of ANGPT1 (Fujikawa et al., 1999; Kim et al., 2000; Papapetropoulos et al., 2000). It is well known that PI3K/AKT is a pathway involved in cell survival and proliferation (Testa and Tsichlis, 2005).
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