Regular ArticleEffects of Cigarette Smoking on Fas/Fas Ligand Expression of Human Lymphocytes☆
References (40)
- et al.
Immunol. Today
(1993) - et al.
Curr. Opin. Biol.
(1995) Adv. Immunol.
(1994)- et al.
Immunity
(1994) - et al.
Toxicol. Appl. Pharmacol.
(1995) - et al.
Cell
(1993) - et al.
J. Neuroimmunol.
(1998) Thorax
(1987)- et al.
Crit. Rev. Toxicol.
(1990) - et al.
Adv. Biosci.
(1993)
Nature
Proc. Natl. Acad. Sci. USA
J. Immunol.
J. Exp. Med.
J. Exp. Med.
Immunol. Today
Nature
Nature
Eur. J. Immunol.
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Impact of cell death pathway genes Fas 21377AA and FasL 2844CC polymorphisms on the risk of developing non-small cell lung cancer
2018, Egyptian Journal of Medical Human GeneticsCitation Excerpt :Also, Zhao et al. (2016) observed that the risk of lung cancer was increased significantly among both smokers and non-smokers with more pronounced increase among heavy smokers than light smokers [29]. Moreover, because tobacco smoking can provoke FasL expression Suzuki et al. (1999) and Bijl et al. (2001) stated another hypothesis for this relation, where the level of FasL expression from the FasL 2844C allele was higher than that from the FasL 2844T allele upon induction by smoking and in addition to the higher constitutive expression resulting from the FasL 2844T/C polymorphism, smoking and FasL 2844CC genotype increase vulnerability of lung cancer [30,31]. Zhang et al. (2005) stated that the high level of environmental smoke that non-smokers exposed to throughout ordinary life may justify the higher risk of lung cancer among non smokers carrying FasL 2844CC genotype when compared with those carrying the same genotype and smoked less than 20 packs per year [18].
FASL-844 T/C polymorphism: A biomarker of good prognosis of breast cancer in the Tunisian population
2012, Human ImmunologyCitation Excerpt :Moreover, the effect of a single polymorphism may be modulated by interaction with environmental and genetic factors. FASL expression can be induced by tobacco smoking [30] and alcohol consumption [31]. However, Crew et al. did not find any association between FASL genotypes and breast cancer risk by smoking status and alcohol consumption among Americans [28].
Nicotine-mediated signals modulate cell death and survival of T lymphocytes
2010, Toxicology and Applied PharmacologyEffects of lifestyle on micronuclei frequency in human lymphocytes in Japanese hard-metal workers
2009, Preventive MedicineCitation Excerpt :Furthermore, smoking may induce apoptosis more than micronuclei, and the deficiency of MN in the very heavy smokers might be explained by the fact that micronucleated cells are preferentially eliminated by apoptosis (Fig. 3). In fact, some studies have shown smoking greatly decreased NK cell numbers in peripheral blood lymphocytes (Li et al., 2007), and smoking (i.e. nicotine) induces apoptosis in human lymphocytes by enhancing expression of Fas (CD95) death receptor (Suzuki et al., 1999), increases apoptotic T cells by decreasing Bcl-2 and IL-7 receptor expression (Hodge et al., 2005). Smoking also induces apoptosis in rat terminal bronchiole through the p53/Bax and JNK/FasL cascade pathway (Wu et al., 2006).
Cigarette smoke aggravates asthma by inducing memory-like type 3 innate lymphoid cells
2022, Nature Communications
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This work was supported in part by the 1995–1998 SRF Foundation grants for Biomedical Research (Tokyo, Japan).
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To whom correspondence and reprint requests should be addressed at Departments of Immunology and Medicine, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511, Japan. Fax: 81-44-975 4347.