Biochemical and Biophysical Research Communications
Regular ArticleOsteoclastogenesis Inhibitory Factor (OCIF) Directly Inhibits Bone-Resorbing Activity of Isolated Mature Osteoclasts☆
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2009, Biomedicine and PharmacotherapyCitation Excerpt :However, the interaction between RANKL and RANK receptor can be blocked by OPG, a secreted glycoprotein which produced and released by osteoblast [19]. OPG competitively binds to RANKL and prevents RANKL from binding and activating RANK, which leads to prevention of osteoclastogenesis, increases apoptosis of mature osteoclasts, inhibits activation of existing osteoclasts and decreases osteoclast number [20–22]. To understand the process of bone formation and remodel between implant materials and bone tissues in detail, it is necessary to assess the effects in the interactions of osteoblasts with implant materials.
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2009, Archives of Oral BiologyCitation Excerpt :Osteoprotegerin, however, is not directly related to osteoclasts, acting as a decoy receptor of RANKL, inhibiting osteoclast formation, but reports of immunohistochemical staining to OPG in osteoclasts have already been described.14 Hakeda et al. 22 have detected an OPG-binding protein of 140 kDa on the plasma membrane of isolated rabbit mature osteoclasts. Binding of OPG to this protein reduced or disrupted the formation of F-actin ring in isolated osteoclasts, the cytoskeletal structure of which is correlated with bone resorption.
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Bilezikian, J. P.Raisz, L. G.Rodan, G. A.
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Corresponding author. Fax: +81-493-71-3523. E-mail:[email protected].