Background: Psoriatic arthritis (PsA) can lead to significant mental burden affecting several aspects of life in majority of patients. Mental health problems, such as depression and anxiety may result in poor treatment adherence and difficulty in coping with disease burden.

Objectives: The aim of this study is to determine the risk factors associated with clinically significant depression and anxiety in patients with PsA.

Methods: The data from 1128 patients with PsA who met CASPAR classification criteria enrolled by Turkish League Against Rheumatism (TLAR)-Network derived from 25 investigating centers. All of the patients underwent clinical, radiological and also laboratory assessment by using standardized protocol. The associations between psychological variables and clinical parameters were assessed by univariate and multivariate analyses.

Results: Of the 1128 patients with PsA (the mean age 46.9 ±12.2,%64 F), 574 (%50.9) had high risk for depression (HADS-D score ≥7) and 270 (%23.9) for anxiety (HADS-A score ≥10). By univariate analysis, the highest odds ratio (OR) associated with both depression and anxiety were SF36-MCS<50 (OR 6.9, [95%CI:5.3–9]; OR 9, [95%CI:6.5–12.6], respectively. The lowest OR associated with depression belong to PASI total score (OR 1.1, [95%CI:1–1.1]), while the lowest OR associated with anxiety belong to BASMI (OR 1.2, [95%CI:1.1–1.3]). Multivariate logistic regression analysis of potential risk factors for mental health revealed that BASFI (OR 1.9, [95%CI:1.3–2.9], BASDAI (OR 1.6, [95%CI: 1.2–2.3]), BASRI (OR 1.1, [95%CI: 1–1.2]), SF36 MCS<50 (OR 4.7,[95%CI: 3.3–6.8) and unemployed (OR 1.4, [95%CI: 1–1.9]) were factors that influence the risk of depression whereas the BASDAI (OR 1.6, [95%CI: 1–2.4]), SF36 MCS<50 (OR 6, [95%CI: 4–9.2]), BASMI (OR 1.2, [95%CI: 1.1–1.3]) and FIRST≥5 (OR 3, [95%CI: 2–4.5]) were factors that influence the risk of anxiety.

Conclusion: This large nationwide database indicated that higher disease activity, functional disability, fibromyalgia (FMS), poor health related quality of life as well as structural damage were estimated as the important risk factors for mental disorders in PsA.

Disclosure of Interests: Gamze Kiliç: None declared, Kemal Nas: None declared, Erkan Kilic: None declared, ibrahim tekeoğlu: None declared, Betul Sargin: None declared, Sevtap Acer Kasman: None declared, Hakan Alkan: None declared, Nilay Sahin: None declared, Gizem Cengiz: None declared, Nihan Cuzdan: None declared, Ilknur Albayrak Gezer: None declared, Dilek Keskin: None declared, Cevriye Mülkoğlu: None declared, Hatice Resorlu: None declared, Şebnem Ataman: None declared, Ajda Bal: None declared, Mehmet Tuncay Duruöz Grant/research support from: Abvie, Speakers bureau: Novartis, AMGEN, Abdi İbrahim, İlko, Okan Kucukakkas: None declared, Ozan Volkan Yurdakul: None declared, Meltem Alkan Melikoglu: None declared, Yildiray Aydin: None declared, Figen Ayhan: None declared, Hatice Bodur: None declared, Mustafa Calis: None declared, Erhan Capkin: None declared, Gul Devrimsel: None declared, SAMI HIZMETLI: None declared, Ayhan Kamanli: None declared, Kevser Gok: None declared, Yasar Keskin: None declared, Hilal Kocabas: None declared, Oznur Kutluk: None declared, Nesrin Şen: None declared, Omer Faruk Sendur: None declared, Murat Toprak: None declared, Sena Tolu: None declared, Tiraje Tuncer: None declared: