Table 4

Comparison of mortality risk, swollen joints, tender joints and functional disability between cohort 1 and cohort 2 over time

N
(number of events)
Age-adjusted and gender-adjusted, HR/SHR (95% CI)Adjusted for baseline variables*, HR/SHR (95% CI)Adjusted for baseline variables* and time-varying smoking, HR/SHR (95% CI)Adjusted for baseline variables* and time-varying treatment/smoking, HR/SHR (95% CI)
Mortality risk†
 Patients with IP1653 (291)0.76 (0.60 to 0.96)0.72 (0.56 to 0.95)0.73 (0.56 to 0.95)0.77 (0.58 to 1.02)
 Patients with RA961 (178)0.87 (0.64 to 1.19)0.83 (0.59 to 1.18)0.85 (0.60 to 1.20)0.95 (0.65 to 1.38)
Cancer mortality risk†
 Patients with IP1653 (91)0.97 (0.64 to 1.49)1.06 (0.66 to 1.73)1.06 (0.65 to 1.72)1.04 (0.60 to 1.77)
 Patients with RA961 (55)1.03 (0.60 to 1.79)1.25 (0.67 to 2.32)1.26 (0.67 to 2.35)1.26 (0.60 to 2.62)
CVD mortality risk†
 Patients with IP1653 (106)0.61 (0.40 to 0.93)0.58 (0.37 to 0.93)0.53 (0.33 to 0.84)0.61 (0.37 to 0.99)
 Patients with RA961 (68)0.69 (0.41 to 1.18)0.61 (0.34 to 1.12)0.61 (0.34 to 1.12)0.79 (0.41 to 1.52)
Respiratory disease mortality risk†
 Patients with IP1653 (43)1.26 (0.67 to 2.35)1.33 (0.67 to 2.66)1.11 (0.54 to 2.28)1.01 (0.45 to 2.25)
 Patients with RA961 (25)1.63 (0.75 to 3.53)1.50 (0.61 to 3.69)1.54 (0.64 to 3.72)1.57 (0.62 to 4.00)