The most frequent comorbidities* according to the claims data from 2015 in patients with axSpA
| Total | Depressive symptoms | P value | |||
| n=1736 | No n=724 (42%) | Mild n=479 (28%) | Moderate/severe n=533 (31%) | ||
| Cardiovascular diseases | |||||
| Hypertensive diseases (I10–I15) | 51.5 | 51.5 | 49.1 | 53.6 | 0.3624 |
| Ischaemic heart diseases (I20–I25) | 12.5 | 13.4 | 11.1 | 12.4 | 0.5153 |
| Diseases of arteries (I70–I79) | 9.5 | 9 | 8.5 | 11.1 | 0.3208 |
| Diseases of veins (I80–I89) | 18.4 | 17.3 | 17.3 | 21 | 0.2059 |
| Mental disorders | |||||
| Depressive disorders (F32, F33) | 22.2 | 12.6 | 22.9 | 34.6 | <0.0001 |
| Anxiety disorders (F40, F41) | 9.5 | 6.1 | 8.4 | 14.9 | <0.0001 |
| Reaction to severe stress, and adjustment disorders (F43) | 9.8 | 7.3 | 7.6 | 15.3 | <0.0001 |
| Somatoform disorders (F45) | 21.2 | 14.7 | 21.2 | 29.9 | <0.0001 |
| Neurological disorders | |||||
| Nerve, nerve root and plexus disorders (G50–G59) | 11.7 | 9 | 9.8 | 17.1 | <0.0001 |
| Polyneuropathies (G60–G64) | 8.4 | 5.9 | 7.9 | 12.2 | 0.0006 |
| Sleep disorders (G47) | 9.9 | 8.5 | 9.6 | 12.2 | 0.1022 |
| Obstructive sleep apnoea (G47.31) | 2.9 | 2.5 | 3.7 | 2.7 | 0.4671 |
| Musculoskeletal disorders (other than axSpA) | |||||
| Osteoarthritis (M15–M19) | 35.9 | 34.6 | 36.2 | 37.5 | 0.5771 |
| Spondylosis (M47) | 24.2 | 18.8 | 24.3 | 31.4 | <0.0001 |
| Other soft tissue disorders, not elsewhere classified (M79) | 26.4 | 22.6 | 24.2 | 33.5 | <0.0001 |
| Fibromyalgia (M79.7) | 4.5 | 1.9 | 4.9 | 7.7 | <0.0001 |
| Disorders of bone density (M80–M85) | 13.1 | 14 | 13.1 | 12 | 0.5929 |
| Metabolic and endocrine disorders | |||||
| Disorders of thyroid gland (E00–E07) | 28.2 | 28 | 28.2 | 28.6 | 0.9775 |
| Diabetes mellitus (E10–E14) | 16.2 | 16.9 | 14.2 | 16.9 | 0.4036 |
| Type two diabetes mellitus (E11) | 14.3 | 14.2 | 12.9 | 15.6 | 0.5172 |
| Overweight (E65–E68) | 14.7 | 14.4 | 12.6 | 17.2 | 0.1295 |
| Respiratory tract diseases | |||||
| Chronic obstructive pulmonary disease (J44) | 8.8 | 9.3 | 6.3 | 10.2 | 0.0790 |
| Asthma bronchiale (J45) | 9.9 | 9.2 | 9.2 | 11.5 | 0.3269 |
| Gastrointestinal diseases | |||||
| Diseases of oesophagus, stomach and duodenum (K20–K31) | 24.5 | 23.4 | 23.4 | 27 | 0.2874 |
Values are presented as percentages. P values were assessed using Rao-Scott χ2 tests. P values <0.05 are shown in bold.
*With prevalence of ≥10% in at least one WHO-5 group excluding axSpA and EAMs.
AxSpA, axial spondyloarthritis; EAMs, extra-articular manifestations.