Table 1

Clinical data of patients included in the study

Bone marrow samples for transcriptome analysisBlood samples for transcriptome analysisBone marrow samples for flow cytometry analysisBlood samples for flow cytometry analysisSynovial fluid and blood samples used for cytometric analysisBlood samples for flow cytometry analysis (validation cohort)Synovial fluid and serum samples used for ELISA
RA patientsQA patientsRA patientsQA patientsRA patientsQA patientsRA patientsQA patientsRA patientsRA patientsND (healthy donors)RA patientsQA patients
No. of patients8866119119612121716
Gender, no. female/no. male8/04/45/12/410/17/210/17/261010/210/214/310/6
Age, years55 (48.5–58.5)55 (53.75–58.5)56 (54.5–58.25)54.5 (52.5–61)59 (55.5–60.5)59 (52–64)59 (55.5–60.5)59 (52–64)31.5 (23.5–58.25)49 (40.75–53)36.6 (31.05–43.50)59  (51–69)61.5 (54–67.5)
RF positive, (%)66.766.773.3
ACPA positive, (%)507557
TJC281 (1–1)5.5 (3–9)9 (3–12)2 (1–2.25)
SJC281 (1–1)3 (1.75–6)2 (1–5)1 (1–2)
VAS disease activity (0–10 cm)5 (4.25–6.25)5 (3.75–7)6 (4–6.25)5 (4–6)
ESR (mm/L h)26 (10.25–34)6 (3–15)27 (24.5–46.75)9.5 (4.25–13.25)18 (12.5–34)12 (11–21)18 (12.5–34)12 (11–21)29 (23.25–34.75)24.5 (17–26.5)6 (5.5–6)43 (25.75–64)18 (9–23)
CRP (mg/dL)6.35 (3.5–9.8)1.52 (0.60–3.68)0.52 (0.47–0.70)
DAS28-ESR3.82 (3.67–3.85)4.51 (4.15–5.52)5.48 (3.80–6.08)3.74 (3.29–4.13)
  • Values provide the median with IQR.

  • ACPA, anticyclic citrullinated peptide antibodies; CRP, C reactive protein; DAS28, Disease Activity Score in 28 joints; ESR, erythrocyte sedimentation rate; ND, healthy donor; OA, osteoarthritis; RA, rheumatoid arthritis; RF, rheumatoid factor; SJC28, 28 joint swollen joint count; TJC28, 28 joint tender joint count; VAS, visual analogue scale.