Table 1

Demographics showing characteristics of study population key. Data presented as means and SD.

Advanced OAMild OATissue control
Number*721210
Age range
Mean (SD)		51–88
69.1 (7.7)		49–79
62.2 (8.5)		21–88
56.2 (27.7)
Gender
Female N (%)		55 (76.4)9 (75)9 (90)
Body mass index
Mean (SD)		32.5 (5.7)28.8 (3.9)N/A
WOMAC pain
Mean (SD)		59.4 (21.3)30.9 (20.3)N/A
WOMAC stiffness
Mean (SD)		62.8 (25.4)33.0 (29.7)N/A
WOMAC function
Mean (SD)		59.8 (20.6)34.0 (24.3)N/A
NRS pain
Mean (SD)		5.7 (2.3)2.6 (2.4)N/A
HADS
Mean (SD)		12.6 (7.2)9.6 (6.7)N/A
MOAKS* N (%)
BML		MOAKS=0
MOAKS=1
MOAKS=2
MOAKS=3		9 (14.1)
52 (81.3)
3 (4.6)
0 (0)		4 (57.1)
3 (42.9)
0 (0)
0 (0)		N/A
Synovitis/effusion
N (%)		MOAKS=0
MOAKS=1
MOAKS=2
MOAKS=3		2 (3.1)
28 (43.8)
18 (28.1)
16 (25)		2 (28.6)
2 (28.6)
1 (14.2)
2 (28.6)		N/A
Cartilage damage
N (%)		MOAKS=0
MOAKS=1
MOAKS=2
MOAKS=3		0 (0)
16 (25)
41 (64.1)
7 (10.9)		4 (57.1)
3 (42.9)
0 (0)
0 (0)		N/A
Clinical ManagementUnderwent knee replacement surgeryMedical managementUnderwent other surgery

  • BML, bone marrow lesion; HADS, Hospital Anxiety and Depression Scale; MOAKS, MRI Knee Osteoarthritis Score; NRS, Numerical Rating Scale; OA, osteoarthritis; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index.