Etanercept | Infliximab | Adalimumab | Certolizumab | Golimumab | P | |
---|---|---|---|---|---|---|
N=1651 | N-1366 | N=1004 | N-921 | N=626 | ||
Observed percentage | ||||||
On drug | 70.6 | 66.4 | 69.2 | 65.2 | 68.0 | |
EULAR good response* | 28.0 | 23.9 | 25.9 | 24.3 | 27.8 | |
DAS28 remission* | 25.9 | 21.3 | 26.0 | 22.4 | 27.7 | |
HAQ improvement* | 28.0 | 24.5 | 29.0 | 25.0 | 24.8 | |
28 Joint counts = 0* | 23.3 | 16.8 | 20.4 | 19.0 | 21.6 | |
Adjusted† relative risk (95% CI) | ||||||
On drug | Ref. | 0.94 (0.89–1.00) | 0.98 (0.92–1.04) | 0.90 (0.84–0.96) | 0.97 (0.90–1.04) | 0.02 |
EULAR good response* | Ref. | 0.82 (0.70–0.96) | 0.95 (0.80–1.12) | 0.84 (0.70–1.01) | 0.96 (0.79–1.17) | 0.10 |
DAS28 remission* | Ref. | 0.83 (0.70–0.98) | 1.02 (0.85–1.21) | 0.89 (0.74–1.08) | 1.00 (0.82–1.23) | 0.12 |
HAQ Improvement* | Ref. | 0.82 (0.70–0.96) | 1.04 (0.89–1.21) | 0.86 (0.73–1.03) | 0.86 (0.71–1.05) | 0.02 |
28 Joint count = 0* | Ref. | 0.74 (0.61–0.89) | 0.91 (0.75–1.11) | 0.85 (0.69–1.04) | 0.91 (0.73–1.13) | 0.03 |
*LUNDEX corrected (1). †Sex, age, disease duration, RF, co-treatment (methotrexate, glucocorticoids.)