Table 1

	Total population			Biologic naive			Biologic experienced

	CCP+	CCP+		CCP+	CCP+		CCP+	CCP+

	abatacept initiators n=330	TNFi initiators		abatacept initiators	TNFi initiators		abatacept initiators	TNFi initiators

	n=330	n=330		n=97	n=97		n=233	n=233

Primary outcome:	Mean (±SE)	Mean (±SE)	p value*	Mean (±SE)	Mean (±SE)	p value*	Mean (±SE)	Mean (±SE)	p value*
Change in CDAI	–9.9 (±0.8)	–8.5 (±0.8)	0.24	–9.8 (±1.4)	–12.3 (±1.4)	0.19	–9.9 (±1.0)	–7.0 (±1.0)	0.033
Secondary outcomes:	Response rate (%)	Response rate (%)	p value^†	Response rate (%)	Response rate (%)	p value^†	Response rate (%)	Response rate (%)	p value^†
LDA	41.3	39.7	0.69	50.0	57.0	0.36	37.6	32.1	0.26
Remission	15.5	14.8	0.83	19.6	21.6	0.72	13.7	12.0	0.58
mACR20	36.4	36.4	>0.99	40.2	45.4	0.47	34.8	32.6	0.62
mACR50	24.8	21.5	0.31	26.8 7 37.1	0.12	24.0	15.0	0.014
mACR70	13.6	10.6	0.23	17.5	19.6	0.71	12.0	6.9	0.057

*t-test, ^†chi-square test.