| RA-BEGIN | RA-BEAM | RA-BUILD | RA-BUILD | RA-BEACON | RA-BEACON | ||
|---|---|---|---|---|---|---|---|
| Bari 4mg | Bari 4mg | Bari 2mg | Bari 4mg | Bari 2mg | Bari 4mg | ||
| N=30 | N=104 | N=154 | N=164 | N=117 | N=124 | ||
| Durability of Response, n (%) | |||||||
| SDAI ≤11 | Wk12 OS | 13 (43.3) | 48 (46.2) | 59 (38.3) | 69 (42.1) | 31 (26.5) | 46 (37.1) |
| Wk24 OS | 18 (60.0) | 59 (56.7) | 87 (56.5) | 106 (64.6) | 40 (34.2) | 56 (45.2) | |
| Wk52 OS | 23 (76.7) | 74 (71.2) | |||||
| Wk48 LTE | 23 (76.7) | 77 (74.0) | 98 (63.6) | 106 (64.6) | 54 (46.2) | 62 (50.0) | |
| Wk96 LTE | 25 (83.3) | 73 (70.2) | 86 (55.8) | 92 (56.1) | 54 (46.2) | 62 (50.0) | |
| HAQ-DI imp≥0.22 | Wk12 OS | 28 (93.3) | 80 (76.9) | 118 (76.6) | 118 (72.0) | 85 (72.6) | 97 (78.2) |
| Wk24 OS | 27 (90.0) | 85 (81.7) | 121 (78.6) | 121 (73.8) | 88 (75.2) | 92 (74.2) | |
| Wk52 OS | 24 (80.0) | 86 (82.7) | |||||
| Wk48 LTE | 25 (83.3) | 77 (74.0) | 113 (73.4) | 115 (70.1) | 75 (64.1) | 80 (64.5) | |
| Wk96 LTE | 26 (86.7) | 80 (76.9) | 98 (63.6) | 105 (64.0) | 58 (49.6) | 79 (63.7) | |
| Maintenance of Response at 96 wks, % (n/N') | |||||||
| SDAI ≤11 | R | 82.6 (19/23) | 81.1 (60/74) | 70.9 (61/86) | 66.7 (68/102) | 77.5 (31/40) | 77.8 (42/54) |
| NR | 85.7 (6/7) | 43.3 (13/30) | 36.9 (24/65) | 36.2 (21/58) | 27.8 (20/72) | 27.7 (18/65) | |
| HAQ-DI imp≥0.22 | R | 87.5 (21/24) | 84.9 (73/86) | 72.7 (88/121) | 71.9 (87/121) | 56.8 (50/88) | 71.7 (66/92) |
| NR | 83.3 (5/6) | 38.9 (7/18) | 30.3 (10/33) | 39.0 (16/41) | 27.6 (8/29) | 40.6 (13/32) | |
Data were analysed using nonresponder imputation without considering rescue status in LTE. N = number of mITT pts; N' = number of responders (R) or nonresponders (NR) at entry into LTE; n = number of pts in the specific category.