Table 1.

PK Parameters over All Subjects for BI 695501 via PFS or AI

Parameter	PFS		AI		Adjusted gMean ratio (AI/PFS)*	2-sided 90% CI*

	n	Adjusted gMean*	n	Adjusted gMean*

AUC_0–∞^† [μg·h/mL]	35^‡	2270	35	2280	100.22	82.13, 122.29
AUC_0–1032 [μg·h/mL]	35^‡	1960	35	1960	100.14	85.15, 117.76
C_max [μg/mL]	36	3.76	35	4.14	110.19	96.80, 125.44

*Adjusted for treatment and BMI group as fixed effects; ^†Based on observed last concentration values; ^‡AUC values could not be calculated for one subject (Subject 1001-0110), due to the lack of appropriate terminal phase (only one non-BLQ [below the limit of quantification] value in the elimination phase).