| Age, mean (SD), years | 55.46 (13.21) | 48.34 (12.38) | 7.11 (3.26, 10.96)** | 0.124 |
| Female, n (%) | 41 (33.3) | 82 (66.7) | ns | 0.173 |
| Current smoking, n (%) | 12 (21.4%) | 54478.6) | 2,84 (1.37–5.89)** | 0.37 (0.16, 0.86)* |
| Caffeine, n (%) | 33 (29,2%) | 80 (70,8) | 2.35 (1.26 -4.39)** | 0.092 |
| Functional status > In (%) | 38 (29.0%) | 93 (71.0) | 3,23 (1.65–6.31)** | 2.39 (1.06, 5.40)* |
| Extra-articular involv, n (%) | 7 (20,6%) | 27 (79.4) | 2,63 (1.08–6.43)* | 0.107 |
| MTX adverse events, n (%) | 20 (24,1%) | 63 (75,9) | 2.85 (1.50–5.40)** | 0.44 (0.20, 0.95)* |
| Baseline DAS28PCR, mean (SD) | 3.88 (0.56) | 4,75 (0,76) | -0,87 (-1.06, -0.67)** | 5.79 (2.99, 11.20)** |
| MTX delay, mean (SD), m | 1.66 (3.91) | 5,39 (18.57) | -3.73 (-7.28, -0.18)* | 0.089 |