Description of psychiatric symptoms registered in the database for TNF-α inhibitors
| Characteristics | Patients (Total = 71) |
|---|---|
| Major psychiatric symptoms: | 11 (15%) |
| – Manic episode | 8 (11%) |
| – Acute psychosis | 3 (4%) |
| Minor psychiatric symptoms: | 60 (85%) |
| – Anxiety/Nervousness | 10 (14%)/6 (8%) |
| – Insomnia or decreased need for sleep | 31 (44%) |
| – Psychomotor agitation/Aggressiveness | 6 (8%)/8 (11%) |
| – Hallucinations | 7 (10%) |
| – Libido exacerbation | 2 (3%) |
| – Euphoria, grandiosity | 4 (6%) |
| – Derealization, depersonalization | 3 (4%) |
| Psychiatric side effect improved: | 45 (63%) |
| – TNF-α Inhibitors withdrawn | 32 (45%) |
| – TNF-α Inhibitors not withdrawn | 9 (13%) |
| – Missing data | 4 (6%) |
| Psychiatric side effect did not improved: | 16 (22%) |
| – TNF-α Inhibitors withdrawn | 8 (11%) |
| – TNF-α Inhibitors not withdrawn | 4 (6%) |
| – Missing data | 3 (4%) |
| Missing data improved/not improved | 10 (14%) |