Baseline values of and changes in DCE-MRI parameters for MCP2–4 and PIP2–4
| Baseline | Change week 0–week 1 | Change week 0–week 2 | Change week 0–week 4 | Change week 0–week 8 | Change week 0–week 16 | |
|---|---|---|---|---|---|---|
| Median change [number] | PBO+CZP/CZP | PBO+CZP/CZP | PBO+CZP/CZP | PBO+CZP/CZP | PBO+CZP/CZP | PBO+CZP/CZP |
| Nvoxel | ||||||
| MCP2–4 | 295/131 | NA/-503 | 62/0 | NA/0 | 90/53 | NA/-473 |
| [5]/[12] | [1]/[4] | [1]/[5] | [2]/[4] | [1]/[5] | ||
| PIP2–4 | 108/144 | -35/0 | -56/-12 | -80/-75 | -69*/10 | -32/-12 |
| [8]/[15] [3]/[6] | [5]/[7] | [5]/[4] | [7]/[10] | [5]/[8] | ||
| IRE | ||||||
| MCP2–4 | 0.000/0.004 | NA/0.000 | 0.006/0.00 | NA/0.000 | 0.273/-0.023 | NA/0.002 |
| [4]/[9] | [0]/[3] | [2]/[2] | [0]/[4] | [2]/[2] | [0]/[5] | |
| PIP2–4 | 0.013/0.006 | -0.002/-0.001 | 0.000/0.001 | 0.003/0.000 | 0.014*/0.000 | 0.000/0.023 |
| [8]/[10] | [2]/[3] | [5]/[5] | [5]/[3] | [5]/[5] | [4]/[2] | |
| ME | ||||||
| PIP2–4 | 0.013/0.006 | -0.002/-0.001 | 0.000/0.001 | 0.003/0.000 | 0.014*/0.000 | 0.000/0.023 |
| [8]/[10] | [2]/[3] | [5]/[5] | [5]/[3] | [5]/[5] | [4]/[2] | |
| PIP2–4 | 1.76/1.99 | -0.16/-0.30 | -0.17/0.02 | -0.23/0.03 | -0.02/-0.01 | -0.19/-0.12 |
| [8]/[10] | [2]/[3] | [5]/[5] | [5]/[3] | [5]/[5] | [4]/[2] | |
NA: Not applicable. Difference between time points: Wilcoxon Signed Ranks test: *p<0.05.