| MTX (N=210) | Bari 4 mg (N=159) | Bari 4 mg + MTX (N=215) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Week: 0 | 4 | 12 | 32 | 0 | 4 | 12 | 32 | 0 | 4 | 12 | 32 |
| ALC: 1890 | -110* | -110* | -80 | 1920 | 310*** | 380*** | -20 | 1940 | 410*** | 220*** | -100* |
| CD3+: 1384 | -108*** | -98.5** | -102.5*** | 1369 | 148*** | 207*** | -78* | 1403.5 | 210*** | 90** | -150*** |
| CD8+: 435 | -36** | -45*** | -48*** | 422 | 52*** | 69*** | -34** | 435 | 80.5*** | 27* | -63*** |
| CD19+: 261 | -17.5 | -10 | -13 | 258 | 103*** | 113*** | 51*** | 269 | 119*** | 101*** | 46*** |
| NK: 218 | -11 | -25** | -23** | 247 | 74*** | 49*** | -24** | 234 | 64*** | 14 | -44*** |
Data are mean (Wk 0) and LSM Δ from BL (Wks 4, 12, 32), last observation carried forward. *p<0.05, **p≤0.01, ***p≤0.001 within grp comparison, LSM Δ from BL. Reference ranges (cells/μL): ALC=800–4280; CD3+=603–2990; CD8+=125–1312; CD19+=107–698; NK=95–64.