Categories of evidence: Ia, evidence for meta-analysis of randomised controlled trials; Ib, evidence from at least one randomised controlled trial; IIa, evidence from at least one controlled study without randomisation; IIb, evidence from at least one other type of quasi-experimental study; III, evidence from non-experimental descriptive studies, such as comparative studies, correlation studies and case–control studies; IV, evidence from expert committee reports or opinions or clinical experience of respected authorities, or both LOA: 0–10 numerical rating scale.

*Typical features include usage-related pain, short duration morning stiffness, age >40, symptoms affecting one or a few joints.

OA, osteoarthritis; US, ultrasonography.