Susceptibility loci with at least suggestive evidence of association with sJIA
| Top SNP | Chr | Position | Ref/Alt | Best p Value | Model | OR (CI) | i2 | Strata | Samples | Closest gene(s) |
|---|---|---|---|---|---|---|---|---|---|---|
| rs41291794 | 6 | 32425762 | A/T | 3.6×10−15 | Additive | 2.1 (1.8 to 2.6) | 0.64 | 9 | 7711 | HLA-DRA |
| rs72632736 | 1 | 4449204 | A/G | 2.9×10−9 | Additive | 2.4 (1.8 to 3.3) | 0 | 7 | 7075 | LOC284661, AJAP1 |
| rs1823549 | 1 | 103147831 | T/C | 3.2×10−7 | Additive | 0.4 (0.3 to 0.6) | 0 | 6 | 6816 | COL11A1 |
| rs1178121 | 7 | 18762652 | C/A | 3.4×10−7 | Dominant | 1.6 (1.3 to 1.9) | 0.24 | 8 | 7513 | HDAC9 |
| rs12517545 | 5 | 73680314 | G/A | 5.2×10−7 | Dominant | 0.6 (0.5 to 0.8) | 0 | 9 | 7711 | ENC1, LOC101929082 |
| rs79575701 | 18 | 45579621 | C/A | 6.2×10−7 | Additive | 3.4 (2.1 to 5.5) | 0 | 4 | 4822 | ZBTB7C |
| rs114940806 | 1 | 44558672 | A/G | 1.2×10−6 | Additive | 3.0 (1.9 to 4.7) | 0.47 | 5 | 5137 | KLF17 |
| rs1279094 | 9 | 11706771 | T/C | 1.2×10−6 | Additive | 1.3 (1.2 to 1.5) | 0 | 9 | 7712 | LOC101929446 |
| rs864089 | 3 | 64244118 | T/C | 1.4×10−6 | Dominant | 0.6 (0.5 to 0.8) | 0 | 8 | 7516 | PRICKLE2 |
| rs481331 | 10 | 43003048 | A/T | 1.4×10−6 | Additive | 1.5 (1.3 to 1.7) | 0 | 9 | 7712 | ZNF37BP, ZNF33B |
| rs8097070 | 18 | 23086307 | A/G | 1.6×10−6 | Additive | 0.3 (0.2 to 0.5) | 0 | 4 | 4993 | ZNF521, SS18 |
| rs1527934 | 8 | 117392156 | C/T | 1.8×10−6 | Additive | 1.7 (1.4 to 2.1) | 0 | 6 | 6926 | EIF3H, LINC00536 |
| rs78507369 | 16 | 78305293 | A/G | 2.0×10−6 | Additive | 3.0 (1.9 to 4.6) | 0 | 4 | 4857 | WWOX, LSM3P5 |
| rs12445022 | 16 | 87575332 | G/A | 2.4×10−6 | Dominant | 1.5 (1.3 to 1.7) | 0.36 | 9 | 7715 | LOC101928737, JPH3 |
| rs112165031 | 2 | 112902227 | G/A | 2.5×10−6 | Additive | 2.5 (1.7 to 3.7) | 0.58 | 5 | 6917 | FBLN7 |
| rs6853094 | 4 | 116576274 | C/A | 2.6×10−6 | Additive | 1.6 (1.3 to 1.9) | 0.22 | 8 | 7564 | RPF2P2, PGAM4P2 |
| rs73401585 | 10 | 109690236 | T/C | 2.6×10−6 | Additive | 3.2 (2.0 to 5.2) | 0 | 4 | 4824 | LOC101927573, SORCS1 |
| rs9595973 | 13 | 49286438 | G/A | 2.8×10−6 | Dominant | 2.8 (1.8 to 4.3) | 0.5 | 4 | 6845 | CYSLTR2 |
| rs9633402 | 1 | 247946160 | G/A | 3.0×10−6 | Dominant | 0.4 (0.2 to 0.6) | 0 | 9 | 7708 | TRIM58 |
| rs62438583 | 6 | 75326244 | T/G | 3.4×10−6 | Dominant | 0.7 (0.6 to 0.8) | 0 | 9 | 7712 | LOC101928516, COL12A1 |
| rs62359376 | 5 | 52411328 | G/A | 3.6×10−6 | Dominant | 1.7 (1.4 to 2.2) | 0.13 | 8 | 7516 | LOC257396, MOCS2 |
| rs1501138 | 4 | 16397067 | T/C | 4.0×10−6 | Dominant | 0.3 (0.2 to 0.5) | 0.24 | 8 | 7517 | LDB2, TAPT1, ZEB2P1 |
| rs7712113 | 5 | 4985443 | G/C | 4.5×10−6 | Dominant | 3.7 (2.1 to 6.5) | 0.68 | 4 | 4661 | LINC01020, LOC101929176 |
| rs1885747 | 14 | 93047455 | A/G | 4.6×10−6 | Additive | 1.4 (1.2 to 1.7) | 0.38 | 8 | 7513 | RIN3, LGMN |
| rs111580313 | 16 | 86621219 | C/T | 4.8×10−6 | Dominant | 1.7 (1.4 to 2.2) | 0 | 7 | 7368 | MTHFSD, FOXL1, FOXC2 |
Best p value, meta-analytic p value corrected for gender and ancestry under the model specified in the Model column. Model, the genetic model (either additive or dominant) that showed the strongest association between the SNP and sJIA. I2, I2 test for heterogeneity. Strata, number of strata included in meta-analysis. Samples, number of samples included in meta-analysis.
Alt, alternate allele; Chr, chromosome; Ref, reference allele; sJIA, systemic juvenile idiopathic arthritis; SNP, single nucleotide polymorphism;