Table 1

Selected associations between T, J and TJ cluster mitochondrial DNA and OA prevalence, progression and incidence of OA

StudyOriginHaplogroupTrait studiedTotal NEffect (95% CI)
p value		Reference
Case–controlSpainJOA prevalence2557 OA, 1339 controlsOR=0.57 (0.46 to 0.71) p<0.0000110
Case–controlUKJOA prevalence7846 OA, 5402 controlsOR=1.19 (0.72 to 1.95) ns10
Case–controlUKTOA prevalence453 OA, 280 controlsOR=0.57 (0.35 to 0.940 p<0.0279
CHECK cohortThe NetherlandsTOA progression431 OAHR=0.645 (0.419 to 0.978) p<0.0515
OAIUSATOA progression891 OAHR=0.50 (0.28 to 0.88) p<0.0524
Spanish OA cohortSpainTOA progression281 OAHR=0.69 (0.38 to 1.28) ns25
Meta analysisTOA progression1603 OAHR=0.61 (0.45 to 0.82) p=0.00115
CHECK cohortThe NetherlandsJTOA progression431 OAHR=0.71 (0.50 to 0.96) p<0.0515
OAIUSAJTOA progression891 OAHR=0.81 (0.59 to 1.11) ns.15
Spanish OA cohortSpainJTOA progression281 OAHR=0.80 (0.50 to 1.26) ns15
Meta analysisJT1603 OAHR=0.77 (0.62 to 0.94) p=0.00915
CHECK cohortThe NetherlandsJOA incidence635HR=0.73 (0.47 to 1.00) p<0.057
OAIUSAJOA incidence2579HR=0.68 (0.47 to 0.97) p<0.057
Meta analysisJOA incidence3214HR=0.70 (0.54 to 0.91) p=0.0067

  • OA, osteoarthritis; OAI, osteoarthritis initiative.