Primary association of the HLA region in JIA ILAR categories
| Category | HLA variant primary association | Position | p Value | Amino acid residue | OR | 95% CI |
|---|---|---|---|---|---|---|
| Systemic JIA | HLA-DRB1*11 | 32660042 | 3.41×10−11 | 2.09 | 1.67 to 2.59 | |
| Persistent oligoarthritis | HLA-DRB1 AA pos 13 | 32660109 | 9×10−256 | Glycine | 2.72 | 2.41 to 3.08 |
| Extended oligoarthritis | HLA-DRB1 AA pos 13 | 32660109 | 1.05×10−104 | Glycine | 2.87 | 2.4 to 3.42 |
| RF-negative polyarthritis | HLA-DRB1 AA pos 13 | 32660109 | 4.29×10−99 | Glycine | 2.02 | 1.76 to 2.32 |
| RF-positive polyarthritis | HLA-DRB1 AA pos 13 | 32660109 | 3.65×10−31 | Histidine | 2.44 | 2.0 to 2.97 |
| ERA | HLA-B*27 | 31431272 | 8.81×10−98 | 1.71 | 1.32 to 2.24 |
ERA, enthesitis-related arthritis; HLA, human leucocyte antigen; ILAR, International League of Associations for Rheumatology; JIA, Juvenile idiopathic arthritis; RF, rheumatoid factor.