| 0–2 years | 3–5 years | 6–10 years | >10 years | p | |
|---|---|---|---|---|---|
| (n=107) | (n=45) | (n=50) | (n=79) | ||
| Unadjusted outcomes | |||||
| Mean (SE) Δ in CDAI | −10.22 (1.19) | −7.82 (1.83) | −6.16 (1.74) | −4.63 (1.38) | 0.017 |
| LDA, n (%)* | 53/91 (58.2) | 17/32 (53.1) | 15/33 (45.5) | 23/56 (41.1) | 0.21 |
| Remission, n (%)† | 29/103 (28.2) | 11/40 (27.5) | 12/48 (25.0) | 11/72 (15.3) | 0.23 |
| Adjusted outcomes‡ | |||||
| Mean (SE) Δ in CDAI | −9.65 (1.02) | −8.60 (1.53) | −6.77 (1.45) | −4.58 (1.19) | 0.015 |
| LDA, OR (95% CI)* | Reference | 0.89 (0.37, 2.10) | 0.49 (0.21, 1.18) | 0.36 (0.17, 0.78) | 0.048 |
| Remission, OR (95% CI)† | Reference | 0.85 (0.35, 2.05) | 0.57 (0.24, 1.35) | 0.32 (0.13, 0.77) | 0.055 |
*CDAI ≤10 among those with moderate or high disease activity. †CDAI ≤2.8 among those with low, moderate or high disease activity. ‡Adjusted by age, sex, baseline CDAI and prior number of cDMARDs. OR = odds ratio.